Noncatalytic protein component of elastase from horse leucocytes. A protein with regulatory function
Potempa, J.; Korzus, E.; Silberring, J.; Dubin, A.
International Journal of Biochemistry 20(1): 105-108
1988
ISSN/ISBN: 0020-711X
PMID: 3342921
DOI: 10.1016/0020-711x(88)90019-5
Accession: 005991498
1. Noncatalytic protein component (NPC), a strongly acidic protein (pH = 4.5) was separated from native horse leucocyte elastase 1. 2. This protein reduces elastinolytic properties of elastases: 1 and 2A probably by decreasing their isoelectric points. 3. A possible regulatory role of this protein may be inferred from a higher affinity of elastase 1 to NPC rather than to elastin.