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Nonspecific macrophage migration inhibitory factor like activity induced by the synthetic immuno adjuvant n acetylmuramyl l alanyl d iso glutamine



Nonspecific macrophage migration inhibitory factor like activity induced by the synthetic immuno adjuvant n acetylmuramyl l alanyl d iso glutamine



Biochemical and Biophysical Research Communications 85(2): 684-690



N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP), which represents the active part of mycobacteria for adjuvanticity, can inhibit the migration of [guinea-pig] peritoneal exudate cells. This inhibitory action of MDP is not due to cytotoxicity because colchicine, which inhibits MIF [macrophage migration inhibitory factor], restores the migratory properties of MDP treated cells, and pretreatment of peritoneal cells with MDP has no influence on their subsequent migration. There could be a relation between structural requirements for adjuvant activity and macrophage migration inhibition because the D-D-stereoisomer of MDP, which is inactive as an adjuvant, has no inhibitory properties.

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Accession: 005994754

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