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Norepinephrine release from the lung by sympathetic nerve stimulation inhibition by vagus and methacholine

Norepinephrine release from the lung by sympathetic nerve stimulation inhibition by vagus and methacholine

Life Sciences 20(8): 1425-1429

A procedure to isolate the sympathetic nerve supply to the lung was developed in the rabbit. Electrical stimulation (50V, 1ms, 10Hz) of these nerves released norepinephrine (NE) which could be measured in the outflows from lungs perfused via the pulmonary artery. On the average 19 ng NE/stimulation period were found in the perfusates. The release of NE from the lung by nerve stimulation is thereby demonstrated by direct measurement of the amine. Infusion of methacholine (1 or 10 .mu.g/ml) and excitation of the vagus nerves inhibited the output of NE. These data suggest existence of a sympathetic-parasympathetic presynaptic balance in the lung.

Accession: 005995893

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PMID: 853874

DOI: 10.1016/0024-3205(77)90371-x

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