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Object discrimination by rats: the role of frontal and hippocampal systems in retention and reversal

Object discrimination by rats: the role of frontal and hippocampal systems in retention and reversal

Physiology & Behavior 24(1): 33-38

Whether the reversal deficit in nonspatial discrimination tasks following frontal or hippocampal system damage was a result of the spatial components of those tasks or a general reversal deficit, was determined. Rats were trained to choose between 2 objects based on the stimulus characteristics of the objects themselves; neither the absolute location of the objects in the test arena, nor the position of the objects with respect to the rat, accurately predicted the correct choice. Rats with either frontal cortex or fimbria-fornix lesions performed worse than controls in both postoperative retention and reversal of the object discrimination. The performance of rats with frontal cortex damage was impaired during the first 2 postoperative reversals, but not during subsequent reversals. The performance of rats with fornix lesions was impaired only on the 1st postoperative reversal. The nonspatial reversal impairment following damage to either the frontal cortical or hippocampal systems is the result of a general reversal deficit, and is not due to the spatial components of nonspatial tasks.

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Accession: 006010282

Download citation: RISBibTeXText

PMID: 7384248

DOI: 10.1016/0031-9384(80)90010-4

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