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On the ideas alternative to the theory of superoxide mediated oxygen toxicity



On the ideas alternative to the theory of superoxide mediated oxygen toxicity



Bulletin of the Polish Academy of Sciences Biological Sciences 35(1-3): 25-32



Physiological effects of superoxide dismutase deficiency (SOD) resulting from two nonallelic mutations were studied. The data obtained suggest, that secondary effects of superoxide dismutase deficiency are the consequences of lowered ability of the mutant cells to neutralize deleterious effects of intracellulary formed superoxide radical. Therefore, there is no reason to believe, that CuZnSOD* possesses any additional alternative to its superoxide dismutase activity. This activity is involved in protecting yeast cells against toxic effects of paraquat.

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