+ Translate

On the ideas alternative to the theory of superoxide mediated oxygen toxicity

, : On the ideas alternative to the theory of superoxide mediated oxygen toxicity. Bulletin of the Polish Academy of Sciences Biological Sciences 35(1-3): 25-32

Physiological effects of superoxide dismutase deficiency (SOD) resulting from two nonallelic mutations were studied. The data obtained suggest, that secondary effects of superoxide dismutase deficiency are the consequences of lowered ability of the mutant cells to neutralize deleterious effects of intracellulary formed superoxide radical. Therefore, there is no reason to believe, that CuZnSOD* possesses any additional alternative to its superoxide dismutase activity. This activity is involved in protecting yeast cells against toxic effects of paraquat.

(PDF 0-2 workdays service)

Accession: 006027694

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Bannister, W.H.; Bannister, J.V., 1982: Adipocytes do not falsify the superoxide theory of oxygen toxicity. Febs Letters 142(1): 42-43

Suzuki, Y.J.; Ford, G.D., 1994: Mathematical model supporting the superoxide theory of oxygen toxicity. The discovery of superoxide dismutase was followed by a proposal that superoxide anion radical (O2.-) is a major factor in oxygen toxicity. The knowledge of superoxide chemistry, however, led some chemists to conclude that since O2.- is not very r...

Clarkson S.P.; Large P.J.; Boulton C.A.; Bamforth C.W., 1991: Synthesis of superoxide dismutase catalase and other enzymes and oxygen and superoxide toxicity during changes in oxygen concentration in cultures of brewing yeast. The physiological effects on brewing yest, growing in semi-defined wort medium, of a sudden transition from aerobiosis to anaerobiosis were studied. Two yeast strains were examined, used for ale and lager fermentations respectively. The reverse tr...

Lewis-Molock, Y.; Suzuki, K.; Taniguchi, N.; Nguyen, D.H.; Mason, R.J.; White, C.W., 1994: Lung manganese superoxide dismutase increases during cytokine-mediated protection against pulmonary oxygen toxicity in rats. Parenteral injection of the cytokines interleukin-1 and tumor necrosis factor, or of endotoxin (lipopolysaccharide), protects rats against lethal pulmonary oxygen toxicity. To determine the potential importance of manganese superoxide dismutase (M...

Steinkühler, C.; Mavelli, I.; Melino, G.; Rossi, L.; Weser, U.; Rotilio, G., 1988: Copper complexes with superoxide dismutase activity enhance oxygen-mediated toxicity in human erythroleukemia cells. Annals of the New York Academy of Sciences 551: 133-136

Yusa T.; Crapo J.D.; Freeman B.A., 1984: Liposome mediated augmentation of brain superoxide dismutase and catalase inhibits central nervous system oxygen toxicity. Enzymes specific for O2- and H2O2 metabolism [superoxide dismutase (SOD) and catalase] can be delivered to the rat brain following entrapment in liposomes and i.v. injection and will protect against hyperbaric O2-induced convulsions in rats. Lipos...

Yusa T.; Crapo J.D.; Freeman B.A., 1984: Inhibition of central nervous system oxygen toxicity by liposome mediated augmentation of brain superoxide dismutase and catalase. Japanese Journal of Anesthesiology 33(11 SUPPL): S259, S263, 14

Rich, R.F.; Zaltman, G., 1977: Toward a theory of planned social change: alternative perspectives and ideas. Evaluation: 41-47

Alvarez, J.G.; Touchstone, J.C.; Blasco, L.; Storey, B.T., 1987: Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa. Superoxide dismutase as major enzyme protectant against oxygen toxicity. Spontaneous lipid peroxidation in washed human spermatozoa was induced by aerobic incubation at 32 C and measured by malonaldehyde production; loss of motility during the incubation was determined simultaneously. Malonaldehyde production at the po...

Copin, J.C.; Li, Y.; Gascher, Y.; Calagui, B.; Hasegawa, K.; Epstein, C.; Chan, P.H., 1998: Loss of sensitivity to oxygen toxicity due to low oxygen pressure preconditioning in manganese-dependent superoxide dismutase knockout astrocytes. Society for Neuroscience Abstracts 24(1-2): 984