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On the influence of a leaky tight junction on water and solute transport in epithelia


Journal of Theoretical Biology 67(1): 61-84
On the influence of a leaky tight junction on water and solute transport in epithelia
The role of a leaky tight junction of epithelia is examined by considering the flow of water and solute through a channel consisting of 2 sections representing the intercellular space and tight junction. Two cases are considered: flow through a channel with a circular cross-section and flow between parallel planes. Analytical solutions are obtained using the isotonic convection approximation. The flow is driven by active transport of solute and imposed concentration and pressure differences. Particular attention is paid to the flux of solute through the tight junction. The shape of the channel cross-section is probably important. The theory is applied to the rat proximal tube epithelium. The emergent osmolarity is probably close to that predicted for a closed tight junction, but transepithelial hydrostatic pressure differences are potentially important. The influence of transepithelial concentration differences appears to be unimportant in this model.

Accession: 006027872

PMID: 881870

DOI: 10.1016/0022-5193(77)90185-0

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