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Ophiobolin g and ophiobolin h new fungal metabolites from a novel source aspergillus ustus



Ophiobolin g and ophiobolin h new fungal metabolites from a novel source aspergillus ustus



Journal of Agricultural & Food Chemistry 32(4): 778-782



Two new metabolites, ophiobolin G (C25H34O2) and ophiobolin H (C25H38O3), were isolated from A. ustus. The structure of ophiobolin G was unequivocally established by single-crystal X-ray diffraction studies; that of ophiobolin H was deduced from 1H and 13C NMR studies. Both compounds are unusual in that the ring fusion between rings A and B is trans (as opposed to cis in other fungal ophiobolins) and there is a C16-C17 cis double bond. Both inhibited etiolated wheat coleoptile growth at 10-3, 10-4 and 10-5 M. Both inhibited growth of Bacillus subtilis cultures, but ophiobolin H was a more potent inhibitor at rates above 250 .mu.g/disk than ophiobolin G. Neither inhibited growth of Escherichia coli. Ophiobolin H also induced hyperacusia in day old chicks at rates up to 375 mg/kg, but there was no mortality.

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