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Opiates and thermo regulation in mice 3. agonist antagonists

Opiates and thermo regulation in mice 3. agonist antagonists

Journal of Pharmacology and Experimental Therapeutics 220(3): 468-475

The effects of 10 opioid agonist-antagonists on mouse body temperature were examined over a wide range of doses and at 2 fixed temperatures. Mice were minimally restrained and rectal temperatures were monitored after injection of opioid agonist-antagonists using indwelling thermistor probes at ambient temperatures of 20 and C. The drugs tested were 10 agonist-antagonists representing 5 different chemical classes. At C, the lowest doses of cyclazocine, ketocyclazocine, N-allylnormetazocine, pentazocine, levallorphan and butorphanol produced hyperthermia and the higher doses produced hypothermia. At C, all these drugs produced hyperthermia over a wide range of doses, but some of the highest doses still produced a significant but attenuated hypothermic response. Nalorphine, buprenophrine, diprenorphine and nalbuphine produced hyperthermia at C over a wide range of doses. These responses were virtually unaffected by raising the ambient temperature to C. Evidently, these agonist-antagonists fall into 2 groups, one affected by changes in dose and ambient temperature (a response similar to that seen with the agonists) and a 2nd group in which the response to the drug was virtually unaffected by changes in dose or ambient temperature. There appears to be no correlation between agonist or antagonist potency and temperature effect in either of the 2 groups of compounds.

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Accession: 006036682

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