EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Opiates and thermo regulation in mice 3. agonist antagonists



Opiates and thermo regulation in mice 3. agonist antagonists



Journal of Pharmacology and Experimental Therapeutics 220(3): 468-475



The effects of 10 opioid agonist-antagonists on mouse body temperature were examined over a wide range of doses and at 2 fixed temperatures. Mice were minimally restrained and rectal temperatures were monitored after injection of opioid agonist-antagonists using indwelling thermistor probes at ambient temperatures of 20 and 30.degree. C. The drugs tested were 10 agonist-antagonists representing 5 different chemical classes. At 20.degree. C, the lowest doses of cyclazocine, ketocyclazocine, N-allylnormetazocine, pentazocine, levallorphan and butorphanol produced hyperthermia and the higher doses produced hypothermia. At 30.degree. C, all these drugs produced hyperthermia over a wide range of doses, but some of the highest doses still produced a significant but attenuated hypothermic response. Nalorphine, buprenophrine, diprenorphine and nalbuphine produced hyperthermia at 20.degree. C over a wide range of doses. These responses were virtually unaffected by raising the ambient temperature to 30.degree. C. Evidently, these agonist-antagonists fall into 2 groups, one affected by changes in dose and ambient temperature (a response similar to that seen with the agonists) and a 2nd group in which the response to the drug was virtually unaffected by changes in dose or ambient temperature. There appears to be no correlation between agonist or antagonist potency and temperature effect in either of the 2 groups of compounds.

(PDF 0-2 workdays service: $29.90)

Accession: 006036682

Download citation: RISBibTeXText



Related references

Opiates and thermo regulation in mice 2. effects of opiate antagonists. Journal of Pharmacology and Experimental Therapeutics 220(3): 464-467, 1982

Opiates and thermoregulation in mice. III. Agonist-antagonists. Journal of Pharmacology and Experimental Therapeutics 220(3): 468-475, 1982

Opiates and thermo regulation in mice 1. agonists. Journal of Pharmacology and Experimental Therapeutics 213(2): 273-283, 1980

Opiates and thermo regulation in mice 4. tolerance and cross tolerance. Journal of Pharmacology and Experimental Therapeutics 223(3): 702-708, 1982

Pruritus control following epidural opiates through continuous infusion plus self administration of mu antagonists versus mixed agonist antagonists in the post cesarean section population. Anesthesiology (Hagerstown) 73(3A): A941, 1990

Opiates and thermo regulation in the mouse relationship to dose and ambient temperature. Federation Proceedings 37(3): 567, 1978

Stereochemistry of long lasting opiates 2. delta selective opiate antagonists and their agonist analogues. Journal of Organic Chemistry 52(14): 3003-3010, 1987

Effects of opiates and their antagonists on water intake of polydipsic inbred mice. Society for Neuroscience Abstracts 14(2): 1106, 1988

Effects of opiates and opiate antagonists on the Straub tail reaction in mice. British Journal of Pharmacology 36(2): 225-239, 1969

The influence of beta adreno receptor antagonists on thermo regulation during insulin induced hypo glycemia. Journal of Physiology (Cambridge) 308: 26P, 1980

Investigation of the effects of drugs on thermo regulation the role of ambient temperature and operant behavioral thermo regulation. Cooper, K E , P Lomax And E Schoenbaum (Ed ) Drugs, Biogenic Amines And Body Temperature Proceedings Of The Third Symposium on The Pharmacology Of Thermoregulation Banff, Alberta, Canada, Sept 14-17, 1976 Xx+283p Illus S Karger: Basel, Switzerland; New York, N Y , Usa Isbn 3-8055-2395-5 210-218, 1977

An efficient synthesis of 3-OBn-6β,14-epoxy-bridged opiates from naltrexone and identification of a related dual MOR inverse agonist/KOR agonist. Bioorganic & Medicinal Chemistry Letters 22(22): 6801-6805, 2013

Involvement of endogenous opiates in the regulation of gastric emptying of fat meals in mice. Digestive Diseases & Sciences 32(8): 910, 1987

Physiological thermo regulation in the squirrel monkey when behavioral thermo regulation is restricted. Federation Proceedings 32(3 PART 1): 407, 1973