EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Opioidergic control of luteinizing hormone secretion in the female rabbit: influence of age on the response to naloxone



Opioidergic control of luteinizing hormone secretion in the female rabbit: influence of age on the response to naloxone



Canadian Journal of Physiology and Pharmacology 66(1): 38-42



The examine the role of opioid neurons on luteinizing hormone (LH) secretion in the female rabbit, we determined LH release at timed intervals after the naloxone administration to rabbits aged 25-150 days. The LH response to naloxone (10 mg/kg) was not significantly elevated until day 43 when LH rose 76-113% above basal levels at 40-80 min. In 56-day-old females the corresponding increase was 160% at 15 min and in 65- to 67-day-olds it was 154%. From 70 to 80 days of age the LH response was blunted and no significant elevations could be elicited. By contrast, naloxone-induced LH increases were again evident when rabbits were older than 100 days. At all ages no significant change in FSH concentrations was observed. In the adult females, naloxone at 2.5, 5, and 10 mg/kg caused increases in LH secretion which occasionally were high enough to induce ovulation as exemplified by elevation serum progesterone 4 days later. These data suggest that opioid peptides may be involved in the prepubertal rise in LH and in the normal inhibition of adult secretion in the female rabbit.

(PDF same-day service: $19.90)

Accession: 006036971

Download citation: RISBibTeXText

PMID: 3130973

DOI: 10.1139/y88-007



Related references

Opioidergic control of luteinizing hormone release in the female rabbit: influence of ovariectomy and steroid replacement on pulsatile secretion. Biology of Reproduction 39(3): 630-637, 1988

Opioidergic control of gonadotropin secretion in the female rabbit: divergent effects of morphine on secretion of follicle-stimulating hormone and luteinizing hormone. Canadian Journal of Physiology and Pharmacology 67(12): 1486-1492, 1989

Opioidergic control of gonadotropin secretion in the female rabbit divergent effects of morphine on secretion of fsh and luteinizing hormone. Canadian Journal of Physiology & Pharmacology 67(12): 1486-1492, 1989

Naloxone stimulation of luteinizing hormone secretion in the female monkey: influence of endocrine and experimental conditions. Endocrinology 113(5): 1858-1864, 1983

Opioidergic control of luteinizing hormone and prolactin secretion in late gestation in the sow. Biology of Reproduction 55(2): 318-324, 1996

The role of nutrition in the regulation of luteinizing hormone secretion by the opioidergic, dopaminergic, and serotonergic systems in female Mediterranean goats. Biology of Reproduction 84(3): 447-454, 2011

In vivo and in vitro studies on the opioidergic control of the secretion of gonadotropin releasing hormone and luteinizing hormone in sexually immature and adult male rats. Neuroendocrinology 53(6): 579-588, 1991

Opioidergic control of luteinizing hormone and progesterone secretion under changing nutritional regimen in Zebu prepubertal heifers. Journal of Animal Science 72(SUPPL 2): 78, 1994

Luteinizing hormone and luteinizing hormone-releasing hormone secretion is under locus coeruleus control in female rats. Brain Research 955(1-2): 245-252, 15 November, 2002

The role of endogenous opiates in the mechanism of inhibited luteinizing hormone secretion in women with anorexia nervosa the effect of naloxone on luteinizing hormone fsh prolactin and beta endorphin secretion. Journal of Clinical Endocrinology & Metabolism 59(3): 412-416, 1984

Impairment of the opioidergic control of luteinizing hormone secretion in Turner's syndrome: lack of effect of gonadal steroid therapy. Journal of Clinical Endocrinology and Metabolism 66(5): 1024-1028, 1988

Opioidergic and nutritional involvement in the control of luteinizing hormone secretion of postpartum Rasa Aragonesa ewes lambing in the mid-breeding season. Animal Reproduction Science 52(4): 267-277, 1998

Effects of a sustained-release naloxone pellet on luteinizing hormone secretion in female rats. Neuroendocrinology 37(5): 342-348, 1983

Diurnal influences on serum luteinizing hormone responses to opiate receptor blockade with naloxone or to luteinizing hormone-releasing hormone in the immature female rat. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 168(3): 338-343, 1981