EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Opisthorchis viverrini pathogenesis of infection in immunodeprived hamsters



Opisthorchis viverrini pathogenesis of infection in immunodeprived hamsters



Parasite Immunology (Oxford) 8(5): 455-466



Opisthorchis viverrini infections were established in immunologically intact and T cell deprived hamsters. T cell deprivation appeared to have no effect on worm establishment or egg production. Histopathologically, intact and deprived animals showed similar degree of bile duct hyperplasia and periductular fibrosis, though there was a marked reduction in the intensity of the periportal inflammation in the majority of T cell deprived animals. Serum transaminase levels were significantly raised in intact animals by 25 days after infection, whilst levels remained within normal limits throughout the infection period for the majority of the T cell deprived animals. The antibody response to parasite antigens as determined by immunoelectrophoresis, was impaired in T cell deprived animals. Attempts to correlate the serological picture with transaminase levels at three time points after infection and also with the extent of periductular inflammation seen on killing, proved largely unsuccessful. These results indicate that T cell deprivation of the hamster host ameliorates the periductular inflammatory response provoked by O. viverrini in this species. It is suggested that such inflammatory responses are evoked by parasite antigens which gain access to portal tract and surrounding areas, and that such reactions are immunopathological in their outcome to the host, resulting in liver cell death and subsequent replacement of resolving inflammatory and necrotic areas with fibrotic tissue.

(PDF emailed within 0-6 h: $19.90)

Accession: 006037027

Download citation: RISBibTeXText

PMID: 3490651

DOI: 10.1111/j.1365-3024.1986.tb00861.x



Related references

Immunization of hamsters against Opisthorchis viverrini infection. Southeast Asian Journal of Tropical Medicine and Public Health 17(4): 567-573, 1986

MRI and (1)H MRS evaluation for the serial bile duct changes in hamsters after infection with Opisthorchis viverrini. Magnetic Resonance Imaging 31(8): 1418-1425, 2014

Protective immunization of hamsters against Opisthorchis viverrini infection is associated with the reduction of TGF-β expression. Acta Tropica 122(2): 189-195, 2014

Cholangiocarcinoma in experimental hamsters with long-standing Opisthorchis viverrini infection. Asian Pacific Journal of Cancer Prevention 10(2): 299-302, 2009

Granulin Expression in Hamsters during Opisthorchis viverrini Infection-Induced Cholangiocarcinogenesis. Asian Pacific Journal of Cancer Prevention 19(9): 2437-2445, 2018

Effects of physico-chemical factors on the infection of hamsters by metacercariae of Opisthorchis viverrini. Southeast Asian Journal of Tropical Medicine and Public Health 13(4): 614-617, 1982

Equivocal evidence of complete carcinogenicity after repeated infection of Syrian hamsters with Opisthorchis viverrini. Toxicologic Pathology 24(4): 493-497, 1996

Attempts to induce protective immunity in hamsters against infection by a liver fluke of man (Opisthorchis viverrini). Parasitology 86: 127-136, 1983

Relationship between parasite-specific antibody responses and intensity of Opisthorchis viverrini infection in hamsters. Parasite Immunology 22(3): 139-145, 2000

Opisthorchis viverrini infection: pathogenesis and clinical features. Arzneimittel-Forschung 34(9b): 1167-1169, 1984

Ultrastructural hepatic alterations in hamsters and jirds after experimental infection with the liver fluke Opisthorchis viverrini. Parasitology Research 79(5): 357-364, 1993

Enhancement of DEN-induced hepatocellular nodule development by Opisthorchis viverrini infection in Syrian golden hamsters. Carcinogenesis 8(9): 1351-1353, 1987

Opisthorchis viverrini: influence of maternal infection in hamsters on offspring infected with homologous parasite and their IgG antibody response. Experimental Parasitology 113(2): 67-74, 2006

Effect of praziquantel treatment on the expression of matrix metalloproteinases in relation to tissue resorption during fibrosis in hamsters with acute and chronic Opisthorchis viverrini infection. Acta Tropica 111(2): 181-191, 2009

Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase. Carcinogenesis 25(8): 1535-1542, 2004