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Opposite effects of morphine on feeding behavior in rats associated with administration time



Opposite effects of morphine on feeding behavior in rats associated with administration time



Kitakanto Medical Journal 35(5): 451-462



The present study was undertaken to examine how morphine changes food intake in non-fasted or fasted rats with administration time. Morphine (1, 3, 5 and 10 mg/kg) was injected intraperitoneally at 10 : 45 (light period injection) or 18 : 45 (dark period injection). In non-fasted rats, morphine increased food intake for 2 hr after the light period injection, but decreased it for 2 hr after the dark period injection. In fasted rats, morphine decreased food intake for 2 hr after both the light and dark period injections. The orectic effects of morphine during the light period in non-fasted rats were not influenced by adrenalectomy (ADx), adrenodemedullation (ADMx) and streptozotocin (STZ)-induced diabetes, whereas the anorectic effects of morphine during the dark period in nonfasted rats were attenuated by ADx, ADMx and STZ-induced diabetes. Corticosterone (10 mg/kg) itself had no effects on feeding during either the light or dark period. Serum insulin levels were not altered at 15 min. After the light period injection, but markedly decreased at 15 min after the dark period injection. These results show that morphine has opposite effects on feeding behavior according to the time of administration and feeding condition, suggesting that morphine suppresses feeding only during the dark period, presumably through the adrenal function and inhibition of insulin release, but not during the light period.

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