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Oral acute and chronic feeding toxicity tests on green patina basic cupric carbonate in rats studies on the toxicity of green patina basic cupric carbonate i



Oral acute and chronic feeding toxicity tests on green patina basic cupric carbonate in rats studies on the toxicity of green patina basic cupric carbonate i



Journal of the Food Hygienic Society of Japan 26(6): 605-616



The oral acute toxicity and 12-month chronic toxicity of basic cupric carbonate, regarded as the principal ingredient of green patina (Roku-sho in Japanese), were tested in Slc: Wistar rats. In the acute toxicity test, seven groups consisting of 10 five-week-old rats of each sex were orally given basic cupric carbonate in doses of 764-2281 mg/kg. Three or 4 days after administration, hematuria were noted in some male and female rats that received doses of 1,100 mg/kg or more. The necropsy of dead animals revealed hemorrhage of the glandular stomach mucosa and hematuria in the urinary bladder in the same groups. The calculated LD50 values were 1350 mg/kg in males and 1495 mg/kg in females. In the chronic toxicity test, five groups consisting of 42 five-week-old rats of each sex were fed on diets containing basic cupric carbonate at level of 0 (control), 70, 220, 670 and 2,000 ppm for 12 months. Depression of body weight gain was noted in the 2,000 ppm group of both sexes, but no dead animal was observed throughout the test period. There were marked increases of serum GOT, GPT and LDH activities in the male 2,000 ppm group at 1, 3, 6 and 12 months. Histologically, the incidences of single cell necrosis in the liver was increased significantly in the 2,000 ppm group of both sexes. The results suggest that the diet containing basic cupric carbonate at a level of 2,000 ppm was toxic to rats, and that 670 ppm is the maximum no-effect dose under the conditions used.

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