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Outbreak and control of Sendai virus infection in mouse breeding colonies



Outbreak and control of Sendai virus infection in mouse breeding colonies



Nihon Juigaku Zasshi. Japanese Journal of Veterinary Science 43(3): 399-409



An infectious disease with high morbidity and fatality among adult and young mice broke out spontaneously in some breeding colonies of inbred and outbred strains of mice. A hemagglutinating virus was isolated from the pulmonary tissue of diseased mice and identified as Sendai virus (HVJ) by the cross HI [hemagglutination-inhibition] reaction with antiserum against the isolate and known HVJ. Neither pathogenic bacteria nor mycoplasma were detected from any organ of diseased mice. Antibodies against other pathogenic bacteria and murine viruses were negative in the infected mouse colohy. Apparently a single infection with HVJ had caused the outbreak. There was a difference in fatality among mouse strains. Serological and epizootiological examination revealed that these colonies were free of HVJ from 1973 to the time of outbreak in 1977. A rat colony in the same animal house with those infected mouse colonies had already been infected with HVJ. In another animal house outbreaks of [mouse] HVJ infection in the past were attributed to the introduction of commercial mice. Neither reinfection nor production of HVJ antibody was evidenced in mice born after the 1977 outbreak because diseased mice were eliminated from the colony during the outbreak, breeding was discontinued for nearly 2 mo. and antibodies were acquired by surviving mice.

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Accession: 006049166

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PMID: 6275156


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