Section 7
Chapter 6,060

Pancreatic exocrine function in diabetics with special references to oral loads of n benzoyl l tyrosyl p amino benzoic acid and p amino benzoic acid

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Wakayama Medical Reports 25(1): 27-34


ISSN/ISBN: 0511-084X
Accession: 006059166

The pancreatic exocrine function in diabetics was examined by combining an oral BT-PABA [N-benzoyl-L-tyrosyl-p-amino benzoic acid] load (PFD test) and an oral PABA load (PABA test). The excretion ratio of PABA in urine during PFD test (PR) was significantly elevated after 1 mo. of treatment for diabetes mellitus in untreated diabetics. PR was significantly depressed at 70.3 .+-. 12.2% (Mean .+-. SD) in diabetics whose blood sugar (BS) was controlled at constant levels, as opposed to 78.9 .+-. 8.5% in normals (P < 0.01). The depression of PR was particularly pronounced in diabetics with a prolonged duration, high level of fasting BS and severe diabetic retinopathy. To eliminate the influence of all the factors associated with the whole course of BT-PABA from intestinal absorption to urinary excretion, the excretion ratio of PABA in urine during the PABA test (PR') was also examined. Although the PR/PR' ratio in diabetics (84.0 .+-. 14.5%) was significantly lower than that in normals (93.0 .+-. 10.3%) (P < 0.05), little or no relationship between the above factors concerning diabetes mellitus and PR/PR' ratio was recognized. The following steps should apparently be taken to examine the pancreatic exocrine function in diabetics: after the stabilization of the BS levels, a PFD test should be performed and when PR is abnormally low, a PABA test should be done. A low level of PR/PR' ratio may be a sign indicating pancreatic exocrine dysfunction.

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