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Pancreatic lesions of Keshan disease and its significances

Pancreatic lesions of Keshan disease and its significances

Chinese Medical Journal 100(8): 671-676

Keshan disease is an endemic cardiomyopathy in China. A study was made of the histopathologic changes of the pancreas in Keshan disease and non-Keshan disease necropsies. The pancreatic septal atrophy had some pathologic characteristics, in which atrophic acini septally divided the lobules into nodules, and the islets were usually spared. In 92 cases of Keshan disease in Chuxiong district, Yunnan Province [China], the incidence of severe atrophy was 4.35% (40.92). A few cases of pancreatic septal atrophy were also found in the necropsies of non-Keshan disease, but almost all of such cases were only found in various heart diseases. Not a single case of severe septal atrophy was found in portal flow obstructed disease, such as in cirrhosis. The present data indicate that the septal atrophy of the pancreas can hardly be explained only by congestion. It is necessary to determine the relation among the environmental, geochemical and nutritional factors, to establish the acinus atrophy of the pancreas and myocardial necrosis.

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Accession: 006059324

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PMID: 3129250

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