+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Pancreatic tumors induced by a single intra peritoneal injection of aza serine in partially pancreatectomized rats

Cancer Letters 9(1): 43-46

Pancreatic tumors induced by a single intra peritoneal injection of aza serine in partially pancreatectomized rats

Pancreatic tumorigenesis of azaserine by a single i.p. injection after partial pancreatectomy in male Wistar rats was studied. Pancreatic lesions developed in all rats 52 wk after the administration of azaserine at doses of 50 mg (group 1) or 100 mg/kg body wt (group 2). Histologically, there were hyperplastic nodules in 4 of 12 rats and 4 of 7 rats in groups 1 and 2, respectively, adenomas in 100% in both groups, and adenocarcinomas in 2 of 7 rats of group 2. It appears that pancreatic regeneration induced by partial pancreatectomy enhances the azaserine tumorigenesis.

(PDF 0-2 workdays service: $29.90)

Accession: 006059541

PMID: 6768445

Related references

Investigations concerning morphology of tumors induced in rats by intra peritoneal injection of asbestos dusts. Archiv fuer Geschwulstforschung 41(2): 120-136, 1973

A role of nicotinamide-induced increase in pancreatic beta-cell mass on blood glucose control after discontinuation of the treatment in partially pancreatectomized OLETF rats. Diabetes Research and Clinical Practice 41(1): 1-8, 1998

Effects of analgesics on the cortical potentials evoked by the stimulation of dental pulp of rats abstract intra peritoneal injection intra peritoneal injection. Journal of Dental Research 47(6 PART 1): 957, 1968

Delay of hormonally induced diabetes by amino-glutethimide and metyrapone in partially pancreatectomized rats bearing transplantable pituitary tumors. Concomitant failure to prevent splanchnomegaly. Endocrinology 86(1): 107-119, 1970

Changes of blood sugar and ultrastructural alterations of pancreatic b cells in partially pancreatectomized rats. Japanese Journal Of Clinical Electron Microscopy: 475-476, 1975

Natural history of 2 3 7 8 tetra chloro di benzo p dioxin induced liver lesions in rats as observed by transmission electron microscopy during a 32 week period after a single intra peritoneal injection. Journal of Toxicology & Environmental Health 12(4-6): 533-540, 1983

Adaptive response of beta cells in pancreatic islets isolated from partially pancreatectomized rats. Diabetologia 34(SUPPL 2): A86, 1991

Effect of caffeine on pancreatic tumorigenesis by 4 hydroxyamino quinoline 1 oxide in partially pancreatectomized rats. Carcinogenesis (Oxford) 4(1): 17-22, 1983

Tumors of rats after intra peritoneal injection of powdered chrysotile and benzo a pyrene. Zentralblatt fuer Bakteriologie Parasitenkunde Infektionskrankheiten und Hygiene Erste Abteilung Originale Reihe B Hygiene Krankenhaushygiene Betriebshygiene Praeventive Medizin 155(5-6): 463-469, 1972

Tumors of the nervous system in rats after intra peritoneal injection of methylnitroso urea. Zentralblatt fuer Allgemeine Pathologie und Pathologische Anatomie 115(1-2): 3-7, 1972