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Parenteral immunization of pigs against infection with Treponema hyodysenteriae

Parenteral immunization of pigs against infection with Treponema hyodysenteriae

American Journal of Veterinary Research 39(4): 639-642

Six intravenous injections of formalin-inactivated Treponema hyodysenteriae were given to 8 specific-pathogen-free pigs at 6-day intervals. The 8 vaccinated and 8 control pigs were challenged intragastrically with pure cultures of T hyodysenteriae 7 and 8 days after the last intravenous injection. Clinical signs of swine dysentery were observed in all 8 control pigs, but was observed in only 1 of the immunized pigs. Three control pigs died. These findings suggest that parenteral immunization with T hyodysenteriae provided a marked degree of protection against subsequent intragastric challenge exposure with the homologous isolate of T hyodysenteriae.

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Accession: 006063989

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PMID: 148230

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