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Pathogenesis and clinical picture of aujeszkys disease in cattle after experimental infection of respiratory alimentary and reproductive organ and the skin



Pathogenesis and clinical picture of aujeszkys disease in cattle after experimental infection of respiratory alimentary and reproductive organ and the skin



Zentralblatt fuer Veterinaermedizin Reihe B 32(4): 287-305



Experimental infection with Herpesvirus suis Type 1 in cattle showed that the spread of the virus and the ensuring clinical picture are determined by the route of entry. When the virus was given via the respiratory tract (intranasal or intrabronchial instillation; aerosol inhalation) it was found most frequently, in the nervous tissue of the head and in the spinal cord at the 7th cervical vertebra (cranial dispersion of virsu). After virus introduction to the undamaged rectal and vaginal mucosa after s.c. injection in the lumbar region, and after oral administration, the virus was found mainly in the caudal regions of the body and did not penetrate the spinal cord more anteriorly than the 1st thoracic vertebra (caudal virsu dispersion). Cranial virus dispersion resulted in a clinical picture characterized by a short illness with unrest, itching in the head region, spasms of the head and neck local paralysis in the head region and tympany of the rumen. In animals with caudal dispersion the period of illness was longer, there was mild local itching in the caudal regions, clinical signs of colic, activation of abdominal pressure and spasms of the abdominal muscles. Despite the use of large doses of virus, exposure of undamaged skin (.gtoreq. MID50 [50% minimum infective dose]), the eyelid (104.8 or 106 MID50) and the forestomach mucosa (106.8 or 107.0 MID50) infection did not take place; s.c. injection of a dose of virus of 50 MID50 produced infection. Apparently, H. suis Type 1 enters without significant local proliferation in the peripheral nerves and during the incubation period it reaches the CNS. Its centrifugal spread into and through the CNS results in the clinical picture.

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