EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Pathogenesis of 1 2 di methyl hydrazine induced carcinomas in rat intestine 1. induction of mucin producing carcinomas in rat intestine



Pathogenesis of 1 2 di methyl hydrazine induced carcinomas in rat intestine 1. induction of mucin producing carcinomas in rat intestine



Acta Pathologica Japonica 32(2): 257-264



White male Wistar rats (74) were divided into 2 groups and given weekly s.c. injections of 30 mg 1,2-dimethylhydrazine (DMH) 2 HCl/kg body wt for 10 or 15 wk, respectively, and the histological properties and distribution of DMH-induced rat carcinomas were investigated. The carcinomas induced by DMH were classified mainly into mucin-producing and nonmucin-producing carcinomas. In the large intestine, the group treated for 15 wk had significant incidences of mucin-producing carcinomas composed mainly of cells containing intracellular mucin. Mucin-producing carcinomas consisted of poorly differentiated adenocarcinoma, signet ring cell carcinoma and mucinous carcinoma, and these often coexisted within the same tumor mass. Mucin-producing carcinomas tended to develop in the proximal colon and cecum, while nonmucin-producing carcinomas were frequent in the distal colon. This method could be a useful model for study of glycoproteins of cancer cells.

(PDF emailed within 1 workday: $29.90)

Accession: 006070331

Download citation: RISBibTeXText



Related references

Pathogenesis of 1,2-dimethylhydrazine-induced carcinomas in rat intestine. I. The induction of mucin producing carcinomas in rat intestine. Acta Pathologica Japonica 32(2): 257-264, 1982

Pathogenesis of 1 2 di methyl hydrazine induced carcinomas in rat intestine 2. histochemical and ultrastructural characteristics of glyco proteins of 1 2 di methyl hydrazine induced carcinoma cells. Acta Pathologica Japonica 32(2): 265-280, 1982

Pathogenesis of 1 2 di methyl hydrazine induced rat colonic carcinomas electron histochemical characteristics of glyco proteins of carcinoma cells. Journal of Histochemistry & Cytochemistry 30(6): 589, 1982

Mucin of the small intestine in mucinous carcinomas of the colon. Pathology Research & Practice 165(1-2): 107, 1979

Demonstration of ras and p53 gene mutations in carcinomas in the forestomach and intestine and soft tissue sarcomas induced by N-methyl-N-nitrosourea in the rat. Japanese Journal Of Cancer Research. 88(2): 129-136, 1997

Pathogenesis of 1,2-dimethylhydrazine-induced carcinomas in rat intestine. II. Histochemical and ultrastructural characteristics of glycoproteins of 1,2-dimethylhydrazine-induced carcinoma cells. Acta Pathologica Japonica 32(2): 265-279, 1982

Differential expression of human spasmolytic polypeptide (trefoil factor family-2) in pancreatic carcinomas, ampullary carcinomas, and mucin-producing tumors of the pancreas. Digestive Diseases and Sciences 45(4): 659-664, 2000

Induction of adeno carcinomas of the colon in mice by weekly injection of 1 2 di methyl hydrazine. Proceedings Of The American Association For Cancer Research: 0, 1972

Molecular biologic analysis of small intestine carcinomas, what do they have in common with colon carcinomas?. Pathology Research & Practice 196(6): 389, 2000

Diagnosis Of Operability In Patients With Gastric Carcinomas And Large Intestine Carcinomas On The Basis Of Some Laboratory Data. Minerva Chirurgica 20: 23-26, 1965

Experimental adenomas and carcinomas of the large intestine behave as distinct entities most carcinomas arise de novo in flat mucosa. Cancer 47(1): 81-89, 1981

Induction of carcinomas of the colon and rectum using 1 2 di methyl hydrazine implications in terms of early changes during chemical carcinogenesis. Toxicology Letters (shannon) Issue 1): 67, 1980

Induction of small intestine carcinomas in rabbits using methylnitrosourea. Zentralblatt für Allgemeine Pathologie U. Pathologische Anatomie 115(1): 40-47, 1972

Ultrastructure of 1 2 di methyl hydrazine induced adeno carcinomas in rat colon. Journal of the National Cancer Institute 61(5): 1291-1300, 1978