+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Pathogenesis of coronavirus sd in mice 1. prominent de myelination in the absence of infectious virus production



Pathogenesis of coronavirus sd in mice 1. prominent de myelination in the absence of infectious virus production



Archives of Neurology 40(8): 493-498



Following intracerebral inoculation of 3-4-wk C57 B16/J mice with coronavirus SD, 23% exhibited neurologic signs within the 1st wk. Only 6% died. Within the 1st wk after inoculation (AI), a panencephalitis was noted. Prominent demyelination detected in the spinal cord on day 6 continued through day 29 AI. Demyelinated lesions in the spinal cord were either subpial with few inflammatory cells except for macrophages or perivascular with prominent accumulation of lymphocytes, plasma cells and macrophages. Beginning on day 6 AI, IgG was detected in the lesions. Although an infectious virus was detectable in the CNS only through day 12 AI, viral antigen expression continued through day 24. Evidently, coronavirus SD persists in a nonrecoverable form throughout the initial phase of demyelination, day 6 to day 24 AI.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 006070484

Download citation: RISBibTeXText

PMID: 6870610


Related references

The production of recombinant infectious DI-particles of a murine coronavirus in the absence of helper virus. Virology 218(1): 52-60, 1996

Coronavirus sd induced de myelination re myelination in mice effects of treatment with cyclo phosphamide. Neurology 34(3 Suppl. 1): 140-141, 1984

Cell cycle arrest and apoptosis induced by the coronavirus infectious bronchitis virus in the absence of p53. Virology 365(2): 435-445, 2007

Pathogenesis of jhm virus induced de myelination in mice. Journal of Neuropathology & Experimental Neurology 31(1): 163, 1972

Emergence of a coronavirus infectious bronchitis virus mutant with a truncated 3b gene: functional characterization of the 3b protein in pathogenesis and replication. Virology 311(1): 16-27, 2003

Pathogenesis of borna disease virus: granulocyte fractions of psychiatric patients harbor infectious virus in the absence of antiviral antibodies. Journal of Virology 73(8): 6251-6256, 1999

A paradox in the pathogenesis of infection with minute virus of mice mvm parity of infectious virus titers in susceptible and resistant strains of mice despite disparities in the amount of total mvm dna. Abstracts of the General Meeting of the American Society for Microbiology 92: 406, 1992

Virus-specific antibody, in the absence of T cells, mediates demyelination in mice infected with a neurotropic coronavirus. American Journal of Pathology 166(3): 801-809, 2005

Aspects of the pathogenesis and biology of feline infectious peritonitis virus and feline enteric coronavirus. Dissertation Abstracts International, B 44(1): 49-50, 1983

Coronavirus sd produces de myelination in weanling mice. Abstracts of the Annual Meeting of the American Society for Microbiology 82: ABSTRACT T81, 1982

De myelination and re myelination in the optic nerve of mice infected with herpes simplex virus. Neurology 34(3 Suppl. 1): 96, 1984

Differential detection of turkey coronavirus, infectious bronchitis virus, and bovine coronavirus by a multiplex polymerase chain reaction. Journal of Virological Methods 131(1): 86-91, 2006

De myelination induced in mice by avirulent semliki forest virus 2. an ultrastructural study of focal de myelination in the brain. Neuropathology and Applied Neurobiology 8(1): 43-54, 1982

Genetics of xenotropic virus expression in mice part 1 evidence for a single locus regulating spontaneous production of infectious virus in crosses involving nzb b lnj and 129 j strains of mice. Journal of Virology 30(3): 754-758, 1979

The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology. Virology 515: 134-149, 2018