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Pathological features of the colonic tumors induced in rats by the administration of 1 2 di methyl hydrazine



Pathological features of the colonic tumors induced in rats by the administration of 1 2 di methyl hydrazine



Virchows Archiv B Cell Pathology 29(3): 211-224



The parenteral administration of 1,2-dimethylhydrazine [DMH] to rats caused the development of colonic neoplasms in about 90% of animals by 24-30 wk of treatment. Usually there were multiple tumors, with a mean of 2.7/rat. The lesions were classified histologically into adenomata (26% of all tumors) and carcinomata, the latter showing varying degrees of differentiation. No completely anaplastic tumors were seen, and there were none originating in connective tissue. The distributions of the different tumor types along the length of the colon varied. The more benign lesions were situated predominantly in the distal half of the colon, while the poorly differentiated adenocarcinomata were concentrated in the proximal 1/3 of the colon. Adenomata often progressed to frank malignancy in the distal colon. In the proximal part it appeared that tumors frequently developed de novo as poorly differentiated carcinomata. Perhaps regional variations in the kinetic organization of the normal colonic mucosa somehow influence the nature of the neoplastic change induced by DMH, thus accounting for the differences in tumor distribution. After 24 wk of DMH treatment there was only a small increase in the mean number of tumors per rat.

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Accession: 006072085

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PMID: 104430


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