EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Pento barbitone effects on respiration related units selective depression of bulbo pontine reticular neurons






Respiration Physiology 36(2): 201-216

Pento barbitone effects on respiration related units selective depression of bulbo pontine reticular neurons

Respiration related units (RRU) were recorded in cats that were locally anesthetized, vagotomized and immobilized, under 2 different experimental conditions: receiving pentobarbitone i.v. at a dose inducing slight but highly significant changes in phrenic discharge; unanesthetized, with a spinal section at C[cervical]6. RRU characteristics were analyzed in unitary volumes constituted by cubes of a matrix including the brain stem. Four parameters of RRU discharges were compared in cubes = RRU density (RRUD), RRU proportion and 2 indices of respiratory modulation. Cubes were sampled in dorsal and ventral bulbar respiratory nulcei, pneumotaxic center (PC) and 7 fields of the bulbopontine and mesencephalic reticular formation. Using the paired sample method for comparing data cube in the 2 conditions under pentobarbitone, RRU activity was profoundly depressed in the reticular formation surrounding dorsal and ventral bulbar respiratory nuclei, in the region bridging the gap between these and the pneumotaxic center and extending from the pneumotaxic level to the decussation of the brachium conjunctivum. RRU activity was unchanged at the level of dorsal and ventral bulbar respiratory nuclei and in the nucleus parabrachialis medialis (NPBM) and was increased in the Koelliker-Fuse nucleus (KF). In the mesencephalic reticular formation, increased activity was observed for non-modulated units and to a larger extent for units driven by the bulbopontine respiratory system.


Accession: 006079270

PMID: 441574



Related references

Caille D.; Vibert J.F.; Bertrand F.; Hugelin A., 1978: Effects of pento barbitone on brain stem respiration related neurons. Neuroscience Letters SUPPL(1): S14

Caille, D.; Vibert, J.F.; Bertrand, F.; Gromysz, H.; Hugelin, A., 1979: Pentobarbitone effects on respiration related units; selective depression of bulbopontine reticular neurones. Respiration related units (RRUs) were recorded in cats, locally anesthetized, vagotomized and immobilized, under two different experimental conditions: (1) receiving pentobarbitone intravenously at a dose inducing slight but highly significant cha...

Jones T.W.G.; Beany J., 1980: Effect of age and pento barbitone tolerance on pento barbitone depression of calcium 45 uptake by mouse brain synaptosomes. Mechanisms of Ageing & Development 14(3-4): 417-426

Mancia M., 1973: Post synaptic responses of bulbo pontine and mesencephalic reticular neurons induced by stimulation of limbic structures. Electroencephalography & Clinical Neurophysiology: 435-436

Richards C.D., 1971: The selective depression of evoked cortical excitatory post synaptic potentials by pento barbitone. Journal of Physiology (Cambridge) 217(1): 41P-43P

Midrio, M.; Zatti, P., 1961: Effects of adrenaline injected into some nuclei of the bulbo-pontine reticular formation on the rigidity from decerebration in the dog. Bollettino Della Societa Italiana di Biologia Sperimentale 37: 698-700

Margnelli M.; Spreafico R.; Mariotti M.; Mancia M., 1973: Post synaptic responses induced in bulbo pontine and mesencephalic reticular neurons by intra laminar thalamic and medial fore brain bundle stimulation. Electroencephalography & Clinical Neurophysiology 35(4): 437

Fallert M.; Polc P., 1970: Blood pressure stimulation effects in the rabbits locus ceruleus bulbo pontine raphe system and medullary reticular formation. Archiv fuer Kreislaufforschung 62(3-4): 153-166

Nishi K.; Oyama Y., 1983: Accelerating effects of pento barbitone on the inactivation process of the calcium current in helix neurons. The effect of pentobarbitone on Ca2+ current (ICa), separated from other ionic currents, was studied under voltage clamp using a suction pipette technique in Helix neurons. Pentobarbitone depressed the maximal peak amplitude (MPA) of ICa in a conc...

Yacoubi, A.; Meininger, V.; Baudrimont, M., 1977: Typology of the bulbo pontine reticular cells. Network analysis methods were applied to the neurons of the medial bulbopontine reticular formation in the cat. The bifurcation ratio allowed isolation of 2 different cellular patterns: collateral branched cells or CB type and dichotomously branch...