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Pento barbitone effects on respiration related units selective depression of bulbo pontine reticular neurons

Pento barbitone effects on respiration related units selective depression of bulbo pontine reticular neurons

Respiration Physiology 36(2): 201-216

Respiration related units (RRU) were recorded in cats that were locally anesthetized, vagotomized and immobilized, under 2 different experimental conditions: receiving pentobarbitone i.v. at a dose inducing slight but highly significant changes in phrenic discharge; unanesthetized, with a spinal section at C[cervical]6. RRU characteristics were analyzed in unitary volumes constituted by cubes of a matrix including the brain stem. Four parameters of RRU discharges were compared in cubes = RRU density (RRUD), RRU proportion and 2 indices of respiratory modulation. Cubes were sampled in dorsal and ventral bulbar respiratory nulcei, pneumotaxic center (PC) and 7 fields of the bulbopontine and mesencephalic reticular formation. Using the paired sample method for comparing data cube in the 2 conditions under pentobarbitone, RRU activity was profoundly depressed in the reticular formation surrounding dorsal and ventral bulbar respiratory nuclei, in the region bridging the gap between these and the pneumotaxic center and extending from the pneumotaxic level to the decussation of the brachium conjunctivum. RRU activity was unchanged at the level of dorsal and ventral bulbar respiratory nuclei and in the nucleus parabrachialis medialis (NPBM) and was increased in the Koelliker-Fuse nucleus (KF). In the mesencephalic reticular formation, increased activity was observed for non-modulated units and to a larger extent for units driven by the bulbopontine respiratory system.

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Accession: 006079270

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PMID: 441574

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