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Pentobarbital treatment of refractory status epilepticus






Neurology 37(3): 500-503

Pentobarbital treatment of refractory status epilepticus

We studied nine patients with status epilepticus refractory to standard therapy. In all patients so treated, IV pentobarbital terminated seizure activity. Mortality was high (77%) in those treated, but was attributed to underlying pathology and possibly to duration of status epilepticus. Pentobarbital therapy should be initiated within 0 to 2 hours after onset of seizures, with continuous EEG monitoring in an intensive care unit.


Accession: 006079295

PMID: 3822147



Related references

Van Ness P.C., 1988: Pentobarbital in the treatment of status epilepticus refractory to benzodiazepines and phenytoin. Epilepsia 29(5): 689-690

Krishnamurthy, K.B.; Drislane, F.W., 1997: Incidence and management of hypotension in pentobarbital treatment for refractory status epilepticus. Journal of the Neurological Sciences 150(SUPPL ): S98

Van Ness, P.C., 1990: Pentobarbital and EEG burst suppression in treatment of status epilepticus refractory to benzodiazepines and phenytoin. Seven patients with complex partial or secondarily generalized tonic-clonic status epilepticus (SE) refractory to benzodiazepines (BZDs) and phenytoin (PHT) were treated with pentobarbital (PTB) coma with an EEG burst suppression (BSP) pattern. PT...

Claassen, J.; Hirsch, L.J.; Emerson, R.G.; Mayer, S.A., 2002: Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: A systematic review. Background: New continuous infusion antiepileptic drugs (cIV-AEDs) offer alternatives to pentobarbital for the treatment of refractory status epilepticus (RSE). However, no prospective randomized studies have evaluated the treatment of RSE. This s...

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Bleck, Thomas P., 1992: High-dose pentobarbital treatment of refractory status epilepticus A meta-analysis of published studies. Epilepsia 33(SUPPL 3): 5

Osorio, I.; Reed, R.C., 1989: Treatment of refractory generalized tonic-clonic status epilepticus with pentobarbital anesthesia after high-dose phenytoin. We report the results of treatment of refractory generalized tonic-clonic status epilepticus in 17 adults. Of 13 patients who received high-dose phenytoin (PHT, mean dose 23.8 mg/kg), seizure control was sustained in five patients. In 12 cases, an...

Young, R.S.; Ropper, A.H.; Hawkes, D.; Woods, M.; Yohn, P., 1983: Pentobarbital in refractory status epilepticus. Tonic-clinic status epilepticus, which is refractory to phenobarbital, phenytoin, and diazepam, may respond readily to a continuous infusion of pentobarbital. The efficacy of pentobarbital can be monitored at the bedside by electroencephalography....

Holmes, G.L.; Riviello, J.J., 1999: Midazolam and pentobarbital for refractory status epilepticus. Status epilepticus, a serious, life-threatening emergency characterized by prolonged seizure activity, occurs most commonly in pediatric patients. Although initial therapies with agents such as diazepam, phenytoin, or phenobarbital generally termi...