EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Pentylene tetrazole and reflex activity of isolated frog spinal cord






Neurology 28(5): 488-494

Pentylene tetrazole and reflex activity of isolated frog spinal cord

The superfused in vitro frog [Rana pipiens] spinal cord preparation was used to investigate the effects of pentylenetetrazol (PTZ) on the spinal cord. PTZ depressed monosynaptic, but augmented polysynaptic reflexes, and decreased primary afferent depolarization. Concurrently, in Ringer's solution containing sufficient Mg2+ or Co2+ to block synaptic transmission, PTZ antagonized the hyperpolarizing effects on motoneurons and the depolarizing effects on primary afferent fibers of the inhibitory amino acids GABA, .beta.-alanine, taurine and glycine. PTZ did not affect responses to the excitatory amino acids glutamic acid and aspartic acid. PTZ did not alter high affinity uptake by cord slices, K+-evoked release of [3H]GABA from them, or the spinal concentration of GABA. PTZ may produce its excitatory effects by postsynaptic blockade of inhibitory processes mediated by GABA (and possibly by other amino acids).


Accession: 006079360

PMID: 306077



Related references

Pentylene tetrazole an antagonist of gamma amino butyric acid at primary afferents of the isolated frog spinal cord. Neuropharmacology 15(1): 69-71, 1976

Effects of anoxia on the reflex activity of the frog isolated perfused spinal cord. Japanese Journal of Pharmacology 29(SUPPL): 44P, 1979

Effects of folates on reflex activity in the isolated hemisected spinal cord of the frog. South African Journal Of Science: 87, 1982

The effect of folates on the reflex activity in the isolated hemisected frog spinal cord. Journal of Neural Transmission 54(3-4): 239-249, 1982

The effect of porphyrin precursors on monosynaptic reflex activity in the isolated hemisected frog spinal cord. Journal of Neural Transmission 36(1): 71-81, 1975

The effect of folates on reflex activity in the isolated hemisected frog xenopus laevis spinal cord. Journal of Neural Transmission 54(3-4): 239-250, 1982

Reversible depression of the reflex activity of the isolated spinal cord of the frog by the blood of patients with multiple sclerosis. Revue Neurologique 115(2): 242-249, 1966

Relationship between pentylene tetrazole induced seizures and brain pentylene tetrazole levels in mice. Journal of Pharmacology & Experimental Therapeutics 214(3): 589-593, 1980

Characteristics of a sympathetic reflex in the isolated hemisected frog spinal cord. Federation Proceedings 36(3): 516, 1977

The effects of increased extracellular potassium in the isolated spinal cord on the flexor reflex of the frog. Neuroscience Letters 19(2): 203-207, 1980