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Peptide receptor protein relationships steroid feedback in gonadotropin releasing hormone stimulation of the steer anterior pituitary



Peptide receptor protein relationships steroid feedback in gonadotropin releasing hormone stimulation of the steer anterior pituitary



Journal of Steroid Biochemistry 18(3): 297-302



Gonadotropin releasing hormone receptor protein (GnRH.cntdot.RP) purified to homogeneity has several binding sites for its effector hormone, as evidenced from the concentration dependence binding curve. Binding of a fully biologically active iodinated GnRH decreased (P < 0.001) by pretreatment of immobilized receptor protein with physiological concentrations of both main sex steroids, testosterone and estradiol-17.beta. With increasing concentrations of the steroids the binding of 125I-GnRH decreased biphasically for testosterone and multiphasically for estradiol 17-.beta. The findings are conducive to an allosteric receptor model.

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Accession: 006079883

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