EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Peptide synthesis 3. comparative solid phase syntheses of human beta endorphin on poly amide supports using tert butoxycarbonyl and fluorenylemthoxycarbonyl protecting groups


Journal of the Chemical Society Perkin Transactions I (1): 65-74
Peptide synthesis 3. comparative solid phase syntheses of human beta endorphin on poly amide supports using tert butoxycarbonyl and fluorenylemthoxycarbonyl protecting groups
Solid-phase syntheses of the 31 residue peptide human .beta.-endorphin on polar polyamide supports are described. Minimization of acidic reaction conditions by replacement of the customary t-butoxycarbonyl and benzyl-based protecting groups by fluorenylmethoxycarbonyl and t-butyl gave a higher yield of purer product.


Accession: 006079924



Related references

Solid phase synthesis on poly amide supports beta endorphin. Goodman, Murray And Johannes Meienhofer (Ed ) Peptides: Proceedings Of The Fifth American Peptide Symposium San Diego, Calif , Usa, June 20-24, Xii+612p Illus John Wiley And Sons: New York, N Y , Usa; Chichester, England Isbn 0-470-99384-7 503-505, 1977

Peptide synthesis 2. procedures for solid phase synthesis using n alpha fluorenylmethoxycarbonyl amino acids on poly amide supports synthesis of substance p and of acyl carrier protein 65 74 deca peptide. Journal of the Chemical Society Perkin Transactions I (2): 538-546, 1981

Syntheses of 4-[N-(tert-butoxycarbonyl)aminoacyloxymethyl]-3-nitrobenzoic acids for use in the liquid-phase peptide synthesis. Hoppe-Seyler's Zeitschrift für Physiologische Chemie 363(7): 701-708, 1982

Application of poly amide resins to poly peptide synthesis human beta endorphin/. Journal of the Chemical Society Chemical Communications (22): 819-821, 1977

The use of p toluenesulfonic acid for removal of the n t butoxycarbonyl protecting group in solid phase peptide synthesis. Synthetic Communications 21(3): 459-466, 1991

Combination of tert-butoxycarbonyl and triphenylphosphonium protecting groups in the synthesis of substituted hydrazines. Organic Letters 3(15): 2297-2299, 2001

Application of poly amide resins to poly peptide synthesis an improved synthesis of beta endorphin using fluorenylmethoxycarbonyl amino acids. Journal of the Chemical Society Chemical Communications (13): 539-540, 1978

Synthesis of N-tert.-butoxycarbonyl-( alpha-phenyl)aminomethylphenoxyacetic acid for use as a handle in solid-phase synthesis of peptide alpha-carboxamides. International Journal of Peptide and Protein Research 18(5): 451-458, 1981

The N- protecting group for amide bond protection in solid phase peptide synthesis. Tetrahedron Letters 35(3): 463-466, 1994

Removal of tert butyl and tert butoxycarbonyl protecting groups with tri fluoro acetic acid mechanisms byproduct formation and evaluation of scavengers. International Journal of Peptide and Protein Research 12(5): 258-268, 1978