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Peptide therapy of sleep disorder in neurotized rats



Peptide therapy of sleep disorder in neurotized rats



Zhurnal Vysshei Nervnoi Deyatel'nosti Imeni I P Pavlova 33(3): 493-499



As a result of chronic stress, anxiety appeared in rat behavior, motor activity increased, heart rate, quickened blood pressure raised, conditioned instrumental alimentary reflexes missed, the duration of deep phases of sleep lowered, time of falling asleep became longer, the number of awakening increased. The change in quantitative characteristics of sleep was accompanied by its worsening, especially of rapid sleep. Administration of 250 .mu.g/kg of both substance P (SP) and eledoisin hexapeptide (EH), 100-200 .mu.g/kg of delta sleep peptide and 10 .mu.g/kg of ethylcrotil barbiturate improved the rats behavior and sleep parameters. Calypnon accelerated falling asleep. Delta sleep inducing peptide increased sleep duration. SP and EH restored not only the quantitative characteristics of deep phases of sleep but greatly improved their quality: lowered the blood pressure disrupted tachycardia, normalized the conditioned activity.

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