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Peptide yy immuno reactivity is co stored with glucagon related immuno reactants in endocrine cells of the gut and pancreas

Peptide yy immuno reactivity is co stored with glucagon related immuno reactants in endocrine cells of the gut and pancreas

Histochemistry 80(5): 487-492

PYY immunoreactivity was located in intestinal mucosa endocrine (EG) cells containing glucagon-related peptides and also in fetal pancreatic .alpha. cells of rat and man. Radioimmunoassay of human fetal pancreatic extracts revealed the presence of PYY immunoreactivity, the concentration of which declined with age (from 65.42 pmol/g at wk 20 to 17.0 pmol at wk 40; correlation coefficient = -0.893), in contrast to the amount of glucagon which remained statistically constant throughout the same fetal period. The identity of this PYY immunoreactive material with the original 36 amino acid porcine peptide was shown by high pressure liquid chromatography.

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