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Perturbation of alpha amino iso butyric acid transport in human placental membranes direct effects by mercuric chloride methyl mercuric chloride and cadmium chloride



Perturbation of alpha amino iso butyric acid transport in human placental membranes direct effects by mercuric chloride methyl mercuric chloride and cadmium chloride



Teratogenesis Carcinogenesis & Mutagenesis 3(1): 89-100



HgCl2, CH3HgCl and CdCl2 directly affect the human placental syncytiotrophoblast microvillous membrane. These heavy metals alter the facilitated diffusion of .alpha.-aminoisobutyric acid (AIB) into vesicles of this membrane in .mu.M concentrations. HgCl2 abolishes temporal kinetics of AIB transport, inducing an initial increase in AIB transport (27% at 100 .mu.M) but subsequently lowering equilibrium values when compared to equilibrium time points in control. CH3HgCl and CdCl2 inhibited the initial rate of AIB transport (40 and 21%, respectively, at 200 .mu.M), but did not affect the equilibrium value of AIB transported when compared to equilibrium levels in control. These effects were concentration dependent. CH3HgCl was more potent in inhibiting AIB transport than CdCl2. CH3HgCl and CdCl2 effects on AIB transport were observed with minimal preincubation with placental vesicles. Preincubation was necessary for HgCl2-induced perturbation of AIB transport. Cysteine protects against HgCl2 and CH3HgCl-induced effects on AIB transport but did not reverse these pertubations. Hg and Cd-induced placental membrane toxicity result from interactions of these heavy metals with the placental plasma membranes.

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