EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Ph effects on lactate and excess lactate in relation to oxygen deficit in hypoxic dogs



Ph effects on lactate and excess lactate in relation to oxygen deficit in hypoxic dogs



Journal of Applied Physiology 42(1): 44-49



Both hypoxemia and alkalemia increase arterial lactate levels, but excess lactate (XL) may be better related to the true O2 deficit and less subject to the pH effect upon glycolysis. Anesthetized (30 ml/kg pentobarbital sodium) and paralyzed dogs [50] in 5 groups were ventilated with low O2 mixtures. Arterial pH was altered by CO2, hyperventilation and HCO3-so that the average pH of the 5 groups were 6.99, 7.21, 7.34, 7.53 and 7.54 (+ propranolol). Pyruvate and lactate levels rose at rates roughly corresponding to pH. In all animals, rise of lactate (.DELTA.L) XL and net O2 deficit were linear with time and the slope accurately described the rate of rise. When the ratio of XL rate to .DELTA.L rate was plotted against pH, it increased toward unity as pH decreased to 6.9. The ratio of .DELTA.L rate to true O2 deficit rate also showed a significant pH effect by increasing with pH. Ratio of XL rate to true O2 deficit rate was independent of pH. XL may correct for red cell lactate production which is not affected by O2 supply but is influenced by pH.

(PDF emailed within 1 workday: $29.90)

Accession: 006091866

Download citation: RISBibTeXText



Related references

pH effects on lactate and excess lactate in relation to O2 deficit in hypoxic dogs. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology 42(1): 44-49, 1977

Effect of PCO2 on the relation of lactate and excess lactate to O2 deficit. SAM-TR-67-109. Sam-Tr. Usaf School of Aerospace Medicine: 1-8, 1967

Effect of PCO2 on the relation of lactate and excess lactate to O2 deficit. American Journal of Physiology 214(6): 1322-1327, 1968

O2 deficit incurred during hypoxia and its relation to lactate and excess lactate. American Journal of Physiology 213(1): 57-63, 1967

Oxygen deficit incurred during hypoxia and its relation to excess lactate. SAM-TR-66-107. Sam-Tr. Usaf School of Aerospace Medicine: 1-9, 1966

Relative rates of arterial lactate and oxygen-deficit accumulation in hypoxic dogs. American Journal of Physiology 224(5): 1190-1194, 1973

Appearance of excess lactate in anesthetized dogs during anemic and hypoxic hypoxia. American Journal of Physiology 209(3): 604-610, 1965

Aerobic training effects on maximum oxygen consumption lactate threshold and lactate disappearance during exercise recovery of dogs. Comparative Biochemistry & Physiology A 94(4): 743-748, 1989

Oxygen debt, lactate, pyruvate, and excess lactate after muscular work. Journal of Applied Physiology 17: 639-644, 1962

Maximal oxygen debt lactate and excess lactate in men with low hematocrit ratio abstract exercise. Proc Int Union Physiol Sci: 312, 1968

Excess post-hypoxic oxygen consumption is independent from lactate accumulation in two cyprinid fishes. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology 165(1): 54-60, 2013

Control of lactate dehydrogenase lactate glycolysis and alpha amylase by oxygen deficit in barley hordeum vulgare cultivar himalaya aleurone layers. Plant Physiology (Rockville) 75(3): 566-572, 1984

The infusion of Ringer's lactate solution during shock. Changes in lactate, excess lactate, and pH. American Journal of Surgery 122(4): 494-501, 1971

Relation between umbilical cord blood pH, base deficit, lactate, 5-minute Apgar score and development of hypoxic ischemic encephalopathy. Acta Obstetricia et Gynecologica Scandinavica 89(10): 1263-1269, 2010

Co-immobilized L-lactate oxidase and L-lactate dehydrogenase on a film mounted on oxygen electrode for highly sensitive L-lactate determination. Biosensors & Bioelectronics. 11(8): 783-789, 1996