EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

pH regulation of endogenous acid production in subjects with chronic ketoacidosis






American Journal of Physiology 249(2 Pt 2): F220-F226

pH regulation of endogenous acid production in subjects with chronic ketoacidosis

In a previous study of starvation-induced acute ketoacidosis, net ketoacid production was inhibited by acid and facilitated by base ingestion. To determine whether dehydrogen ion modifies net ketoacid production during chronic ketoacidosis, 6 overweight volunteers ingested NaHCO3, NaCl or NH4Cl (2 mmol .cntdot. kg-1 .cntdot. day-1), each for 7 days, during weeks 6-8 of ketogenic dieting. During days 4-7 of each phase, blood bicarbonate was stable but lower in the NH4Cl (19.6 .+-. 0.7 mM) than the NaHCO3 (23.7 .+-. 0.7 mM) phases. Throughout these periods, acid intake differed by 216 mmol/day, whereas acid output differed by 129 mmol/day between the NaHCO3 and the NH4Cl phases. The major contribution to this difference in acid balance was a difference in net organic acid (ketoacid) production. Although blood ketones were stable, ketoacid excretion, reflecting net ketoacid production, was decreased by 59% with acid and increased by 66% with base compared with NaCl (control) ingestion. Thus, in this state of chronic ketoacidosis, challenges to acid-base balance were countered by a rapidly occurring, sustained, reversible, and quantitatively significant modification of net acid production which acted as an effective mechanism for acid-base regulation. [The involvement of the kidneys in maintaining the acid-base balance is discussed.].


Accession: 006092006

PMID: 4025554



Related references

Hood V.L., 1983: Ph regulation of acid production in subjects with chronic stable ketosis. Kidney International Supplement (16): S-339

Hood, V.L.; Tannen, R.L., 1989: Regulation of acid production in ketoacidosis and lactic acidosis. Diabetes/Metabolism Reviews 5(4): 393-409

Relman, A.S.; Relman, A.S.; Lennon, A.J.; Lemann, J., 2000: Endogenous production of fixed acid and the measurement of the net balance of acid in normal subjects. Journal of the American Society of Nephrology 11(11): 2155-2164

van Ypersele de Strihou, C., 1980: Importance of endogenous acid production in the regulation of acid-base equilibrium: the role of the digestive tract. Advances in Nephrology From the Necker Hospital 9: 367-385

Testa R.; Domina A.R.; Virdis M.G.; Celle G., 1986: Serum bile acid profiles after endogenous and exogenous loads of bile acid into the enterohepatic circulation of healthy subjects and patients with chronic liver disease. The three-hour profiles of total serum bile acids (TSBA), after caerulein infusion and oral loading of chenodeoxycholic acid and ursodeoxycholic acid, were studied in healthy subjects and patients with various degrees of chronic liver disease (10...

Hodgkins, P.S.; Schwarcz, R., 1997: Up-regulation of kynurenic acid production in rat brain slices by endogenous 2-oxo acids. Society for Neuroscience Abstracts 23(1-2): 2315

Raskin, I.; Turner, I.M.; Melander, W.R., 1989: Regulation of heat production in the inflorescences of an Arum lily by endogenous salicylic acid. We have recently purified calorigen, the natural trigger for heat production in the inflorescences of Sauromatum guttatum Schott (voodoo lily), a thermogenic plant, and identified it as salicylic acid. Since then an analytical assay was developed...

Zhao, M.; Destache, C.J.; Ohia, S.E.; Opere, C.A., 2011: Role of prostanoid production and receptors in the regulation of retinal endogenous amino acid neurotransmitters by 8-isoprostaglandin E2, ex vivo. The role of enzymes and receptors of the prostanoid pathway in the inhibitory effect of 8-isoprostaglandin E2 (8-isoPGE2) on endogenous amino acid neurotransmitter levels was examined, ex vivo. Freshly isolated bovine eyeballs were injected intrav...

Sivakumaran, M.; Heeley, A.F.; Field, T.; Fairham, S.A., 1996: Evidence for increased endogenous production of orotic acid, an activator of protooncogene, in B-chronic lymphocytic leukaemia. British Journal of Haematology 93(SUPPL 2): 289

Scialla, J.J.; Appel, L.J.; Astor, B.C.; Miller, E.R.; Beddhu, S.; Woodward, M.; Parekh, R.S.; Anderson, C.A.M., 2011: Estimated net endogenous acid production and serum bicarbonate in African Americans with chronic kidney disease. Metabolic acidosis may contribute to morbidity and disease progression in patients with chronic kidney disease (CKD). The ratio of dietary protein, the major source of nonvolatile acid, to dietary potassium, which is naturally bound to alkali prec...