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Phagocytic potential of hairy cells






Scandinavian Journal of Haematology 23(1): 69-79

Phagocytic potential of hairy cells

Hairy-cells (HC) of 10 patients with hairy-cell leukemia were studied with several techniques to evaluate phagocytic potential. Mononuclear cells from normal donors and from patients with acute monocytic leukemia served as controls. Light microscopically HC seemed to have ingested bacteria or latex particles. Cell treatment with lysostaphin, an enzyme that kills extracellular Staphylococcus aureus, showed that almost all ingested bacteria were extracellular. Lanthanum nitrate, added during the fixation procedure for EM, stained the outer cell membrane and the membranes of the HC phagosomes, also indicating that the ingested particles were extracellular. HC showed no increased O2 consumption on bacteria exposure in serum presence. HC showed no lysozyme or peroxidase activity, whereas non-specific esterase activity was much weaker than in monocytes. These findings, which show that HC are essentially non-phagocytic, constitute strong evidence against monocytic origin of the malignant hairy-cell leukemia cells.

Accession: 006092481

PMID: 493873

DOI: 10.1111/j.1600-0609.1979.tb02857.x

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