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Phagocytosis and proliferation of retinal pigment epithelium

Phagocytosis and proliferation of retinal pigment epithelium

Folia Ophthalmologica Japonica 39(1): 31-40

3 kinds of polystyrene particles (3 .mu.m in diameter) with different surface natures, i.e. negative charge, positive charge or hydrophilic, were injected trans-sclerally into the subretinal space of albino rats to clarify the effect of the surface nature of foreign substances on the phagocytosis and proliferation of retinal pigment epithelial cells (RPE). Negatively charged particles were phagocytosed by RPE 6 hours after injection, hydrophilic particles 24 hours after and positive 48 hours after. It is clear that the surface nature of particles resulted in different phagocytosis on set times. Both migration and proliferation of RPE were constantly observed where particles were abundant in the subretinal space. 4 days after injection, almost all the particles had been phagocytosed by migrating cells and fibroblast-like cells, which seemed to have originated from the RPE through metaplasia.

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Accession: 006092569

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