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Phagocytosis by normal polymorphonuclear leukocytes of immune complexes from serum of patients with feltys syndrome and rheumatoid arthritis with special reference to immuno globulin e immune complexes



Phagocytosis by normal polymorphonuclear leukocytes of immune complexes from serum of patients with feltys syndrome and rheumatoid arthritis with special reference to immuno globulin e immune complexes



Acta Pathologica Microbiologica et Immunologica Scandinavica Section C Immunology 92(1): 37-42



Sera from patients with Felty's syndrome, rheumatoid arthritis (RA) and controls were investigated for the presence of immune complexes (IC) using phagocytosis by normal polymorphonuclear leukocytes and direct immunofluorescence technique. IC visible as large cytoplasmic inclusions were seen in 19 of 24 cases of Felty's syndrome, 3 of 16 cases of RA, all 3 patients with extraarticular manifestations and none of 21 control sera. IC containing IgG, IgA and C3 [complement component 3] were found in nearly all positive cases. IgM IC were found in only 8 of the Felty's syndrome cases, IgE in 5 and .beta.-2-microglobulin in 1 case, respectively. A tendency to increasing number of large inclusion positive cells in vitro was found inversely correlated to the number of circulating leukocytes in the Felty patients at the time of serum sampling. Small cytoplasmic inclusions were found both in Felty's syndrome and RA patients and in some of the controls, and IgG and C3 were the most frequent constituents in these cases. As these inclusions were found in all groups it may have little significance. IgE IC as determined by a PEG [polyethyleneglycol] precipitation technique were positive in the same 5 cases of Felty's syndrome with IgE containing inclusions and in 1 case of RA with extraarticular manifestations. The complexed IgE amounted to .apprx. 3% of the total serum concentration of IgE. Phagocytosed IC may be involved in the pathogenesis of neutropenia and contribute to the inflammatory processes in Felty's syndrome.

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