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Phagocytosis in experimental burns






Journal of Surgical Research 21(6): 437-448

Phagocytosis in experimental burns

The variations of phagocytic activity [in rats for Salmonella typhimurium] were measured during a 9-day period following experimental burns. The burns are of an intermediate type; necrosis develops within 2-4 days after thermal trauma and covers up to 10% of total body surface. Phagocytic activity was measured in peripheral blood, spleen and liver by measuring both clearance of bacteria and the bactericidal index of the macrophages. Shortly after burn trauma, a considerable inactivation of the bactericidal index was noticed. The decrease of the phagocytic activity of macrophages in the liver and peripheral blood is important but transient; the decrease of the phagocytic activity of splenic macrophages is drastic and persists unimproved for at least 9 days following burn injury.

Accession: 006092619

PMID: 796589

DOI: 10.1016/0022-4804(76)90169-4

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Related references

Liedberg, C.F., 1961: Antibacterial resistance in burns. II. The effect on unspecific humoral defense mechanisms, phagocytosis. and the development of bacteremia. An experimental study in the guinea pig. It is suggested that the cellular defense mechanisms are adversely affected by the burn trauma.

Meyer, F.L.; Joseph, S.; Hirshfeld, J.W.; Abbott, W.E., 1945: Metabolic Alterations Following Thermal Burns. I. Nitrogen Balance In Experimental Burns. Four dogs were burned and there followed a considerable loss of N extending over a period of about 15 days. After this the dogs began to retain N, but there was no increase in bodyweight until food intake was increased.

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