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Phagocytosis in experimental burns

Phagocytosis in experimental burns

Journal of Surgical Research 21(6): 437-448

The variations of phagocytic activity [in rats for Salmonella typhimurium] were measured during a 9-day period following experimental burns. The burns are of an intermediate type; necrosis develops within 2-4 days after thermal trauma and covers up to 10% of total body surface. Phagocytic activity was measured in peripheral blood, spleen and liver by measuring both clearance of bacteria and the bactericidal index of the macrophages. Shortly after burn trauma, a considerable inactivation of the bactericidal index was noticed. The decrease of the phagocytic activity of macrophages in the liver and peripheral blood is important but transient; the decrease of the phagocytic activity of splenic macrophages is drastic and persists unimproved for at least 9 days following burn injury.

Accession: 006092619

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PMID: 796589

DOI: 10.1016/0022-4804(76)90169-4

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