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Phakomatous choristoma of the lower eyelid with psammoma body formation a light microscopic and electron microscopic study






Ophthalmology 88(12): 1198-1206

Phakomatous choristoma of the lower eyelid with psammoma body formation a light microscopic and electron microscopic study

A firm, round tissue mass, measuring .apprx. 12 mm in diameter, was excised from a 5-mo.-old boy who had a history of a gradually enlarging swelling in the left lower nasal eyelid since birth. Histologically and ultrastructurally, the lesion appeared benign and was composed of a dense connective tissue stroma in which nests, lobules, tubules, cords and sheets of large, pale-staining cuboidal and elongated epithelial cells were surrounded by an irregular, thick PAS[periodic acid Schiff]-positive basement membrane having focal excrescences. The interior of the epithelial islands contained bladder cells, cellular debris, granuloamorphous material and foci of dystrophic calcification; an unusual feature of the lesion was the formation of numerous psammoma bodies. Tumors of lenticular anlage are rare and probably result from displacement or migration of the inferior lens placode cells; alternatively, it may originate from an additional locus of lens vesicle in the primitive surface ectoderm of the lower lid. The lesion enlarges because of the differentiation of the ectopic lenticular cells in an abortive attempt to form a lens within the extraocular and mesodermal environment of the lid.


Accession: 006092852



Related references

Tripathi, R.C.; Tripathi, B.J.; Ringus, J., 1981: Phakomatous choristoma of the lower eyelid with psammoma body formation: a light and electron microscopic study. A firm, round tissue mass, measuring approximately 12 mm in diameter, was excised from a 5-month-old boy who had a history of a gradually enlarging swelling in the left lower nasal eyelid since birth. Histologically and ultrastructurally, the lesi...

Rosenbaum, P.S.; Kress, Y.; Slamovits, T.L.; Font, R.L., 1992: Phakomatous choristoma of the eyelid. Immunohistochemical and electron microscopic observations. Background: A 13-month-old Hispanic boy underwent excision of a congenital inferonasal orbital mass arising from the right lower lid. Results of histopathologic examination of the tumor showed a phakomatous choristoma of the eyelid. An immunohisto...

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