EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Pharmaceutical analysis using micellar electrokinetic capillary chromatography






Journal of Chromatographic Science 26(8): 406-409

Pharmaceutical analysis using micellar electrokinetic capillary chromatography

The potential utility in pharmaceutical analysis of a capillary electrokinetic separation technique that employs a micellar "pseudo-stationary phase" is discussed and illustrated. Chromatograms of separations of vitamin metabolites and derivatized amino acids are presented to illustrate the high efficiency of the technique and the ability to simultaneously separate of the technique and the ability to simultaneously separate that charged and neutral components of pharmaceutical samples. The analytical characteristics of the technique and the importance of optimizing experimental parameters, such as surfactant concentration and capillary column diameter, are discussed and demonstrated with the aid of chromatograms.


Accession: 006092965

PMID: 3215989

DOI: 10.1093/chromsci/26.8.406



Related references

Altria K.D.; Smith N.W., 1991: Pharmaceutical analysis by capillary zone electrophoresis and micellar electrokinetic capillary chromatography. The technique of capillary zone electrophoresis and micellar electrocapillary chromatography have been found to be of use for the analysis of pharmaceuticals and separation from related impurities. The method can give good resolutions and high sep...

Luis, M.Luz.; Corujedo, S.; Blanco, D.; Fraga, Jé.M.G.; Jiménez, A.I.; Jiménez, F.; Arias, J.J., 2008: Micellar electrokinetic capillary chromatography analysis of diuretics in pharmaceutical formulations. This paper describes the development of an electrophoretic method used to analyse diuretics, and its use in the analysis of pharmaceutical formulations. Chlorthalidone, furosemide, hydrochlorothiazide and triamterene were separated in 5 min by mic...

Hancu, G.; Simon, B.; Rusu, A.; Mircia, E.; Gyéresi, Aád., 2013: Principles of micellar electrokinetic capillary chromatography applied in pharmaceutical analysis. Since its introduction capillary electrophoresis has shown great potential in areas where electrophoretic techniques have rarely been used before, including here the analysis of pharmaceutical substances. The large majority of pharmaceutical subst...

Luis, M.L.z; Corujedo, S.; Blanco, D.; Fraga, J.M.G.; Jimenez, A.I.; Jimenez, F.; Arias, J.J., 2002: Micellar electrokinetic capillary chromatography analysis of diuretics in pharmaceutical formulations. This paper describes the development of an electrophoretic method used to analyse diuretics, and its use in the analysis of pharmaceutical formulations. Chlorthalidone, furosemide, hydrochlorothiazide and triamterene were separated in 5 min by mic...

Perez, M.L.B.ilon; Rodriguez, L.C.adros; Cruces-Blanco, C., 2007: Analysis of different beta-lactams antibiotics in pharmaceutical preparations using micellar electrokinetic capillary chromatography. The potential of micellar electrokinetic capillary chromatography (MEKC) for analyzing nine beta-lactants antibiotics (cloxacillin, dicloxacillin, oxacillin, penicillin G, penicillin V, ampicillin, nafcillin, piperacillin, amoxicillin) in differe...

Pérez, M.I.Bailón.; Rodríguez, L.Cuadros.; Cruces-Blanco, C., 2006: Analysis of different beta-lactams antibiotics in pharmaceutical preparations using micellar electrokinetic capillary chromatography. The potential of micellar electrokinetic capillary chromatography (MEKC) for analyzing nine beta-lactams antibiotics (cloxacillin, dicloxacillin, oxacillin, penicillin G, penicillin V, ampicillin, nafcillin, piperacillin, amoxicillin) in different...

Melin, V.; Perrett, D., 2004: A comparative study of microemulsion electrokinetic capillary chromatography and micellar electrokinetic capillary chromatography for the analysis of UV-absorbing compounds in human urine. Separations of human urine by microemulsion electrokinetic chromatography (MEEKC) and micellar electrokinetic capillary chromatography (MEKC) with respect to resolution, migration times and efficiencies were optimized and compared. The optimised M...

Sadecka, J.; Polonsky, J.; Shintani, H., 1994: Current advancement of pharmaceutical analysis by capillary zone electrophoresis, micellar electrokinetic chromatography and isotachophoresis. Die Pharmazie 49(9): 631-641

Huang, H.Y.; Lai, Y.C.eng; Chiu, C.W.n; Yeh, J.M.ng, 2003: Comparing micellar electrokinetic chromatography and microemulsion electrokinetic chromatography for the analysis of preservatives in pharmaceutical and cosmetic products. In this study, separation and determination of nine preservatives ranging from hydrophilic to hydrophobic properties, which are commonly used as additives in various pharmaceutical and cosmetic products, by micellar electrokinetic chromatograpy (M...

Yardimci, C.; Süslü, I.; Ozaltin, N., 2004: Determination of piribedil in pharmaceutical formulations by micellar electrokinetic capillary chromatography. A fast and simple micellar electrokinetic capillary chromatographic method was developed for the analysis of piribedil in pharmaceutical formulations. The effects of buffer concentration, buffer pH, sodium dodecyl sulphate (SDS) concentration, org...