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Pharmacokinetics of oxiracetam following intravenous and oral administration in healthy volunteers



Pharmacokinetics of oxiracetam following intravenous and oral administration in healthy volunteers



European Journal of Drug Metabolism & Pharmacokinetics 9(3): 267-274



The kinetics of oxiracetam [a nootropic agent] after single i.v. and oral doses (2000 mg) were investigated in 4 healthy volunteers. Following i.v. administration, the decline in serum levels showed a prolonged, rapid phase followed by a delayed terminal phase. Mean residence times ranged from 3.9-6.5 h. Volumes of distribution ranged from 0.9-1.81/kg, whereas clearance values ranged from 100-119 ml/h per kg. More than 90% of the i.v. dose was recovered unchanged in the urine within 48 h. Oral administration resulted in peak levels within 1-2 h; thereafter, the decline in serum levels showed a pattern similar to that observed after the i.v. dose; almost 50% of the oral dose was excreted in the urine within 6 h. The absolute availability of oral oxiracetam was 75 .+-. 7%.

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Accession: 006096300

Download citation: RISBibTeXText

PMID: 6519128

DOI: 10.1007/bf03189650


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