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Photocolorimetric method for determining chlorhexidine gluconate in antiseptics






Khimiko-Farmatsevticheskii Zhurnal 18(10): 1271-1273

Photocolorimetric method for determining chlorhexidine gluconate in antiseptics

A highly sensitive method was developed for the quantitative determination of chlorhexidine gluconate used for the treatment of bactericidal surgical dressings. The method is based on the changes in color of sulfonitraso R and sulfonitraso E in the presence of chlorhexidine gluconate. The method can be used for the analysis of other guanidine preparations.


Accession: 006110425



Related references

Reverdy, M.E.; Martra, A.; Fleurette, J., 1986: Application of a micromethod to the study of the bactericidal activity of 2 antiseptics based on chlorhexidine gluconate. Minimal bactericidal concentrations (MBCs) of two antiseptics containing chlorhexidine digluconate (5% for the A solution, 1.5% for the B solution) were determined using a microdilution method. This method is a miniaturization of the Afnor T 72150...

Jurczyk, W.; Kedzia, B.; Kedzia, W.; Masiakowski, J.; Salus, I., 1974: A new method of medical equipment sterilization using chlorhexidine gluconate (hibitane gluconate). Anaesthesia, Resuscitation, and Intensive Therapy 2(3): 217-232

Edmiston, C.E.; Seabrook, G.R.; Johnson, C.P.; Paulson, D.S.; Beausoleil, C.M., 2007: Comparative of a new and innovative 2% chlorhexidine gluconate-impregnated cloth with 4% chlorhexidine gluconate as topical antiseptic for preparation of the skin prior to surgery. Background: Decreasing the microbial skin burden reduces the risk of surgical site infection (SSI). The present study compares the activity of an innovative 2% chlorhexidine gluconate (CHG)-impregnated preoperative skin preparation cloth (PC) wit...

Macinga, D.R.; Edmonds, S.L., 2013: Inclusion of chlorhexidine gluconate in alcohol-based presurgical hand antiseptics: can a product be considered "superior" if it does not meet established efficacy requirements?. American Journal of Infection Control 41(5): 475-476

McCann, M.; Fitzpatrick, F.; Mellotte, G.; Clarke, M., 2016: Is 2% chlorhexidine gluconate in 70% isopropyl alcohol more effective at preventing central venous catheter-related infections than routinely used chlorhexidine gluconate solutions: A pilot multicenter randomized trial (ISRCTN2657745)?. A pilot randomized trial in 3 Irish outpatient hemodialysis units compared 2% chlorhexidine gluconate (CHG) in 70% isopropyl alcohol with routinely used CHG solutions for central venous catheter exit site antisepsis. We found no significant differ...

Olson, L.K.M., 2013: Response to letter, "Inclusion of chlorhexidine gluconate in alcohol-based presurgical hand antiseptics: can a product be considered 'superior' if it does not meet established efficacy requirements?". American Journal of Infection Control 41(5): 476-477

Popovich, K.J.; Lyles, R.; Hayes, R.; Hota, B.; Trick, W.; Weinstein, R.A.; Hayden, M.K., 2012: Relationship between chlorhexidine gluconate skin concentration and microbial density on the skin of critically ill patients bathed daily with chlorhexidine gluconate. Previous work has shown that daily skin cleansing with chlorhexidine gluconate (CHG) is effective in preventing infection in the medical intensive care unit (MICU). A colorimetric, semiquantitative indicator was used to measure CHG concentration o...

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