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Photodegradation of frusemide during storage in burette administration sets


International Journal of Pharmaceutics (Kidlington) 31(1-2): 65-68
Photodegradation of frusemide during storage in burette administration sets
The stability of frusemide (1 mg/ml) in 0.9% w/v sodium chloride infusion has been examined under different lighting conditions, when stored in burette administration sets. Frusemide was found to be stable when exposed to diffuse daylight/fluorescent strip room lighting but decomposed quickly when exposed to sunlight. Prevention of this photodegradation was achieved by covering the burette sets with aluminium foil; however, being opaque, this would make monitoring of infusion rates very difficult in the clinical setting. A more convenient method of preventing photodegradation was the use of Amberset burettes. These are coated with a transparent yellow plastic material which inhibits penetration of light in the wavelength range 220-470 nm. Since frusemide was stable in these latter sets when exposed to sunlight, it is recommended that they are used for frusemide infusions in hospital units in which direct exposure of the drug to sunlight or other ultraviolet light sources is possible.

Accession: 006110486

DOI: 10.1016/0378-5173(86)90213-9

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