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Photolysis and hydrolysis of adenosine 5 phosphate

Photolysis and hydrolysis of adenosine 5 phosphate

Photochemistry and Photobiology 27(6): 703-708

Mild acid hydrolysis of adenosine 5'-di-, tri- and tetra-phosphate (ADP, ATP and ADTP) occurs predominantly in the side chain, yielding Pi and AMP. Photolysis results in breaking of the 5'-C.sbd.O.sbd.P bond, yielding Pi for AMP and mainly condensed phosphates for ADP, ATP and ADTP, together with decomposition products of adenosine. Photolytic breaking of the 5'-C.sbd.O.sbd.P bond is not enhanced by excitation of the strongly absorbing adenine ring followed by energy transfer but results from direct excitation of the very weakly absorbing ribosephosphate-moiety of the molecule. Arguments for this are: cyclic AMP ring to the phosphate-ester bond, is photolyzed at approximately the same rate as AMP, and the rate of disappearance of the strong absorption band due to the adenine ring is higher than the rate of liberation of Pi.

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