Plasma concentration gradient of steroid hormones across human mammary tumours in vivo

Van Landeghem, A.A.; Poortman, J.; Deshpande, N.; Di Martino, L.; Tarquini, A.; Thijssen, J.H.; Schwarz, F.

Journal of Steroid Biochemistry 14(8): 741-747

1981


ISSN/ISBN: 0022-4731
PMID: 7300346
Accession: 006128522

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Abstract
The paraendocrine behavior of human breast tumors was studied in vivo. From 10 women with an established mammary tumor, blood samples were taken during mastectomy from the main internal artery of the mammary gland and from its corresponding vein. In these blood samples esterone, estradiol, 4-androstene-3,17-dione, dihydrotestosterone, testosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate, 5-androstene-3.beta.,17.beta.-diol, cortisol and .alpha.-hydroxydehydroepiandrosterone were estimated. All tumors investigated show a positive or negative gradient for one or more steroid hormones. In vivo human breast tumors are able to modify their own endocrine environment by a wide variety of metabolic conversions. With the exception of 4-androstene-3,17-dione it cannot be concluded whether these metabolic conversions are of significance for the development of mammary tumors because of the inconsistent pattern in the changes of hormone levels between arterial and venous blood.