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Plasma creatinine and sensitivity of the pig to malignant hyper thermia syndrome relationships to 2 red blood cell enzymes phospho hexose isomerase and 6 phospho gluconate dehydrogenase



Plasma creatinine and sensitivity of the pig to malignant hyper thermia syndrome relationships to 2 red blood cell enzymes phospho hexose isomerase and 6 phospho gluconate dehydrogenase



Annales de Genetique et de Selection Animale 10(1): 9-16



A sample of 115 Pietrain pigs, (20-25 kg) and 22 Landrace Belge, (30-35 kg) were exposed to halothane, which triggered the malignant hyperthermia syndrome (MHS). Within 5 min 57 Pietrain and 12 Landrace Belge developed MHS. Blood was collected prior to anesthesia to measure plasma creatinine and to determine enzymatic variations for phosphohexose isomerase (PHI) and 6-phosphogluconate dehydrogenase (6-PGD). A highly significant difference of 0.11 mg creatinine/100 ml plasma exists between MHS and non-MHS pigs. A higher muscle content of MHS pigs is indicated and can be visually observed. A significant correlation of 0.33 exists between conformation score and plasma creatinine. The association between MHS and muscular hypertrophy in the pig is confirmed. A very highly significant linkage disequilibrium exists, in the Pietrain sample, between the Hals locus (responsible for MHS) and the PHI locus. In spite of the association between Hals, the MHS gene and the B variant of this enzyme, the effect of the PHI locus on creatinine was not significant. At the 6-PGD locus, which is in linkage equilibrium with the 2 others, the AA homozygote significantly increases creatinine (by 0.09 mg/100 ml) relative to the other 2 genotypes (AB and BB). The additive genetic variance for creatinine due to the Hal locus explains 36% of the total phenotypic variance. The 6-PGD locus additive variance explains only 6% of the phenotypic variance.

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