+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Plasma levels of di n propyl acetate and clonazepam in epileptic patients



Plasma levels of di n propyl acetate and clonazepam in epileptic patients



International Journal of Clinical Pharmacology and Biopharmacy 15(9): 403-408



Plasma levels of DPA [di-n-propylacetate] and CNP [clonazepam] and associated antiepileptic drugs were measured in groups of 106 and 30 epileptic patients aged from 3-49 yr. A poor correlation between daily oral doses and plasma levels of both drugs was observed when the whole group of patients was considered. A better correlation was seen in a group of adult patients who received DPA and PB (phenobarbital). Children below 10 yr of age disposed both drugs faster than adults, and the difference was significant (P < 0.01) in groups receiving PB as associated drug. Patients medicated with PB and DPA or CNP showed lower plasma levels of both drugs; DPA appeared to cause a decrease of PB clearance which was more marked in children. The clinical significance of fluctuations of daily plasma levels of both drugs were discussed in relationship to the schedule of administration and plasma sampling. Observations on therapeutic ranges and adverse effects of the drugs were reported.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 006130175

Download citation: RISBibTeXText

PMID: 334679


Related references

Fluctuations in free di propyl acetate levels of epileptic patients. Acta Neurologica Scandinavica Suppl. 62(79): 60, 1980

The treatment of therapy resistant epileptic patients with di propyl acetate. Epilepsia 14(4): 467, 1973

Daily fluctuations of di propyl acetate serum level in epileptic patients. Majkowski, J (Ed ) Monographs in Neural Sciences, Vol 5 Epilepsy: A Clinical And Experimental Research; Proceedings Of The 2nd European Regional Conference on Epilepsy, Warsaw, Poland, Oct 5-7, 1978 Xvi+306p S Karger: Basel, Switzerland; New York, N Y , Usa Illus Paper P200-207, 1980, 1981

Di propyl acetate and clonazepam activity in febrile convulsions. Bollettino Societa Italiana Biologia Sperimentale 56(11): 1187-1191, 1980

Effects of treatment with di propyl acetate and ethosuximide on sleep organization in epileptic patients. Acta Neurologica Scandinavica Suppl. 62(79): 22, 1980

The effects of clonazepam on the plasma di phenyl hydantoin level in epileptic patients. Electroencephalography & Clinical Neurophysiology 43(4): 497, 1977

Improved selectivity for high-performance liquid chromatographic determination of clonazepam in plasma of epileptic patients. Journal of Chromatography B 719(1-2): 227-233, 1998

Clonazepam serum levels in epileptic patients determined simply and rapidly by high-performance liquid chromatography using a solid-phase extraction column. Acta Medica Okayama 45(2): 123-127, 1991

The effect of chronic n di propyl acetamide depamide treatment on plasma immuno globulins of epileptic patients. Acta Neurologica 35(2): 115-120, 1980

Clinical evaluation of di propyl acetate a new anti epileptic drug. Brain Nerve (tokyo): 1297-1300, 1969

Effects of chronic treatment with amino oxy acetic acid or sodium n di propyl acetate on brain gamma amino butyric acid levels and the development and regression of cobalt epileptic foci in rats. Journal of Neurochemistry 27(6): 1489-1494, 1976

First clinical results of a new anti-epileptic: sodium di-n-propyl acetate (DPA) specialized under the marketed name, Depakine. Acta Neurologica et Psychiatrica Belgica 69(11): 909-913, 1969

Monitoring plasma concentrations of zonisamide and clonazepam in an epileptic attempting suicide by an overdose of the drugs. Current Therapeutic Research 43(3): 463-467, 1988