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Plasmodium gallinaceum transmission blocking immunity in chickens part 2 the effect of anti gamete antibodies in vitro and in vivo and their elaboration during infection



Plasmodium gallinaceum transmission blocking immunity in chickens part 2 the effect of anti gamete antibodies in vitro and in vivo and their elaboration during infection



Experimental Parasitology 47(2): 194-208



Heat-inactivated serum from chickens with transmission-blocking immunity to P. gallinaceum prevented the in vitro development of ookinetes from gametocytes of P. gallinaceum only when present during the period between the initiation of gametogenesis and the release of the microgametes. When added after this time immune serum failed to suppress ookinete development. Immune serum did not prevent the formation of gametes from gametocytes. Immune serum may contain factors which prevent fertilization of the malarial gametes but which do not affect the development of the zygote once fertilization has taken place. Two distinct reactions of malarial gametes with serum from chickens with transmission-suppressing immunity are described-the gamete-agglutination (AG) reaction and the microgamete surface-fixation (SF) reaction. Both reactions were associated with the immunoglobulin fraction of immune serum. The presence of SF antibodies [Ab] during a blood infection correlated closely with effective transmission-blocking immunity in vivo; AG Ab were present in various circumstances in the absence of transmission-blocking immunity. AG and SF Ab occurred in birds immunized with P. gallinaceum-gamete preparations and during or following infections in unimmunized birds; SF Ab appeared only following the peak of asexual infection in unimmunized birds and were of low titer. In immunized birds blood infections following live challenge invariably boosted low levels of SF Ab. The results of immunization of chickens and rhesus monkeys with gametes of their respective malaria parasites, P. gallinaceum and P. knowlesi, are compared.

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Accession: 006133281

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