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Plasmodium gallinaceum: vaccination in chickens

Plasmodium gallinaceum: vaccination in chickens

Experimental Parasitology 43(1): 231-238

Inoculation into chicken embryos of chick erythrocytes infected with P. gallinaceum (infected erythrocytes obtained from chicks inoculated with sporozoites) produced parasitemias of such low magnitude that it was impossible to continue embryo passages of this malaria. Inoculation of massive doses of parasites (20 .times. 106) produced levels of infections in recipient embryos sufficient to maintain continued passages. Marked morphological changes in parasites were noted as well as loss of virulence. Well over 100 embryo passages were required to restore the parasite to its usual virulence and morphology. When chicks were given s.c. injections of this embryo-adapted strain of malaria at an optimum dosage of 25 .times. 104 parasites/g body weight, the resultant parasitemia was too low for accurate counting, but all animals so treated were completely refractory to challenge with blood parasites. Although protection was complete in chicks vaccinated with parasites from the 13th passage in embryos, vaccinating dosages produced levels of parasitemia too high to be judged adequate for a vaccine. After 24 embryo passages attenuation of the parasite and immunity to challenge on the part of the host were complete.

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Accession: 006133282

Download citation: RISBibTeXText

PMID: 891707

DOI: 10.1016/0014-4894(77)90027-3

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