+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Platelet 5 hydroxytryptamine induced shape change and plasma 5 hydroxytryptamine concentration in reserpine treated rabbits

Platelet 5 hydroxytryptamine induced shape change and plasma 5 hydroxytryptamine concentration in reserpine treated rabbits

Neurosciences 11(1): 29-32

The 5HT-induced shape change of blood platelets, suggested to represent the 5HT receptor sensitivity, and the platelet and plasma 5-HT concentration were measured simultaneously in reserpinized rabbits. Reserpine was given i.m. acutely (one shot) or chronically (once a day for 2 weeks). The platelet 5HT concentration decreased after both acute and chronic administration of reserpine. The plasma 5HT concentration increased after the acute administration, but it remained unchanged after the chronic administration. Similarly, the 5HT-induced shape change decreased after the acute administration, but remained unchanged in the chronic administration. These results suggest that the 5HT-induced platelet shape change may depend on the 5HT concentration in the plasma but not in the platelet. Besides, these results support Pletscher's suggestion that the platelet may be considered as a model for some 5HT receptors of the central nervous system.

(PDF emailed within 1 workday: $29.90)

Accession: 006133710

Download citation: RISBibTeXText

Related references

Platelet shape change induced by 5 hydroxytryptamine in reserpine treated rabbits. Neurosciences 10(SUPPL 7): 173-176, 1984

An assessment of platelet aggregation induced by 5-hydroxytryptamine: Part I After pre-incubation with 5-hydroxytryptamine and reserpine. Journal of Clinical Pathology 24(3): 250-258, 1971

Platelet shape change induced by 5 hydroxytryptamine in chronic schizophrenics under antipsychotic drug treatment. Neurosciences 12(2): 156-157, 1986

Studies on the metabolism of 5-hydroxytryptamine (serotonin). V. Reserpine-induced sedation without depletion of cerebral 5-hydroxytryptamine. Life Sciences 6(23): 2505-2513, 1967

Effect of 5-hydroxytryptamine on isolated aortic strip preparations obtained from untreated and reserpine treated rabbits. Planta Medica 41(3): 295-297, 1981

Urapidil inhibits 5-hydroxytryptamine induced platelet aggregation and 14C-5-hydroxytryptamine uptake in platelets. Current Medical Research and Opinion 12(2): 86-92, 1990

Effects of urapidil on 5-hydroxytryptamine induced platelet aggregation and on 14C-5-hydroxytryptamine uptake in platelets. International Journal of Clinical Pharmacology, Therapy, and Toxicology 28(7): 303-308, 1990

Naftopidil inhibits 5-hydroxytryptamine-induced platelet aggregation and 5-hydroxytryptamine uptake in platelets of healthy volunteers. European Journal Of Clinical Pharmacology. 46(3): 271-274, 1994

Effects of urapidil on 5 hydroxytryptamine induced platelet aggregation and on carbon 14 labeled 5 hydroxytryptamine uptake in platelets. International Journal of Clinical Pharmacology Therapy & Toxicology 28(7): 303-308, 1990

The effect of ketanserin a 5 hydroxytryptamine 2 receptor antagonist on 5 hydroxytryptamine induced irreversible platelet aggregation in patients with cardiovascular diseases. Agents & Actions 16(5): 313-317, 1985

An inhibitory prejunctional 5 hydroxytryptamine 1 like receptor in the isolated perfused rat kidney apparent distinction from the 5 hydroxytryptamine 1a 5 hydroxytryptamine 1b and 5 hydroxytryptamine 1c subtypes. Naunyn-Schmiedeberg's Archives of Pharmacology 332(1): 8-15, 1986

Mediation of 5 hydroxytryptamine induced contraction of the rat urinary bladder via 5 hydroxytryptamine 2 and 5 hydroxytryptamine receptors. British Journal of Pharmacology 89(PROC SUPPL): 547P, 1986

Arterial and splanchnic pictures in rabbits treated with 5-hydroxytryptamine and cholesterol and with 5-hydroxytryptamine, cholesterol and Tween 80. Archivio "de Vecchi" Per L'anatomia Patologica E la Medicina Clinica 53(2): 455-471, 1968

Alniditan, a new 5-hydroxytryptamine-1D agonist and migraine-abortive agent: Ligand-binding properties of human 5-hydroxytryptamine-1Dalpha, human 5-hydroxytryptamine-1Dbeta, and calf 5-hydroxytryptamine-1D receptors investigated with (3H)5-hydroxytryptamine and (3H)alniditan. Molecular Pharmacology 50(6): 1567-1580, 1996

The effects of horseradish peroxidase on the concentration of 5-hydroxytryptamine and platelet counts in blood of rabbits and guinea pigs. Histochemistry 58(1-2): 71-77, 1978