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Platelet aggregation across the myo cardial vascular bed in man part 1 normal vs diseased coronary arteries



Platelet aggregation across the myo cardial vascular bed in man part 1 normal vs diseased coronary arteries



Thrombosis Research 14(2-3): 423-432



Platelet aggregation studies were performed on aortic and coronary venous blood of 28 patients with coronary artery disease. Mean platelet aggregation was significantly lower in coronary venous blood than aortic blood, using epinephrine and ADP as aggregating agents. Platelet counts were lower in coronary venous blood. Platelet aggregation was lower in aortic and coronary venous blood in 12 patients who were taking propranolol than in 16 patients not taking propranolol. Six patients without angiographic evidence of coronary disease exhibited no change in platelet aggregation or counts across the myocardial vascular bed. Platelet aggregation is lower in coronary venous blood in patients with coronary disease. Propranolol decreases aggregation in aortic and coronary venous blood. Lower platelet aggregation in coronary venous blood may be related to removal of reactive platelets or formation of platelet aggregates in diseased coronary vasculature.

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Accession: 006133975

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