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Platelet stimulation and hypotension induced by carrageenans in the rat



Platelet stimulation and hypotension induced by carrageenans in the rat



Journal de Pharmacologie (Paris) 14(4): 449-463



The hypotensive effect of 3 carrageenans [i, .kappa. and .lambda.] and of dextran sulfate in Brown Norway (BN) rats. The plasma of these BN rats was devoid of high MW kininogen and poor in plasma prekallikrein. The hypotensive effect in BN rats was greatly reduced in comparison with the effects in normal rats. It was proportional to the thrombocytopenia induced by the sulfated polysaccharides and absent in rats made thrombopenic by antiplatelet serum. The hypotensive effect in BN rats was reduced by bromophenacyl bromide, mepacrine, aspirin, methysergide, promethazine and CCI 17810 [6[p-(4-phenylacetylpiperazin-1-yl)-phenyl]-4,5-dihydro-3(2H)-pyridazinone], and was unchanged after the administration of cobra venom factor, heparin, amino caproic acid, chloroquine, dexamethasone, lidocaine, propranolol, indomethacin, phenidone, imidazole, adenosine and cyproheptadine. The thrombopenic effect was reduced by methysergide and CCI 17810 and was not modified by bromophenacyl bromide and chloroquine.

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Accession: 006135104

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