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Pleiotropic recessive lethal mutants associated with purine metabolism in drosophila melanogaster

Pleiotropic recessive lethal mutants associated with purine metabolism in drosophila melanogaster

Canadian Journal of Genetics & Cytology 23(3): 411-424

Three kinds of complementing mutants of D. melanogaster assigned to the gua 1, pur 1 and ras loci fail to complement with a single class of recessive lethals, previously designated raspberry lethals (ras-1). These lethals are apparently point mutations. The gua 1, pur 1 and ras loci are closely linked. Their phenotypes implicate defects in 3 components of purine metabolism. The complementation pattern is best explained if the 3 loci are functionally related at the genetic as well as at the metabolic level.

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Accession: 006135627

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